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The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Photobiomodulation therapy using red and near-infrared light can reduce inflammation and aid in healing various conditions.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.

DNA profiling in forensics has improved, but predicting physical traits and ancestry from DNA has limitations and requires ethical consideration.

Stress can worsen skin and hair conditions by affecting the skin's immune response and hormone levels.

Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.

Changing how mesenchymal stromal cells are grown can improve their healing abilities.

Fat tissue-derived cells show promise for repairing body tissues, but more research and regulation are needed for safe use.

Lichen Planus is a less common condition affecting skin and mucous membranes, with various types and associated risk factors, challenging to diagnose, significantly impacts life quality, and may have a risk of cancerous changes in oral lesions.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

Niosomes improve minoxidil skin delivery for hair loss treatment.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Spironolactone treatment increases the amount of testosterone available in the body.

Human skin can make serotonin and melatonin.

Wnt1/βcatenin signaling is crucial for heart repair after injury.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Stem cells are crucial for skin repair and new treatments for chronic wounds.

The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.

Tofacitinib is safe and effective for severe alopecia areata, but hair loss may return 2 months after stopping treatment.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

About 7% to 15% of Iranian women have polycystic ovary syndrome, depending on the criteria used to diagnose it.

Lactate production is important for activating hair growth stem cells.

Lifestyle changes can improve body composition, excess male hormone levels, and insulin resistance in women with PCOS.

Sebocytes play a key role in controlling androgen levels in human skin.

Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.