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Hair follicle samples effectively show how well the drug MK-0752 targets and engages with the Notch pathway.

In this study, the authors reported that taking 20 mg or more of biotin can interfere with thyroid function tests, potentially leading to false diagnoses of conditions like Grave's disease.

This review outlines the various processes activated by the peptide GHK-Cu in tissue remodeling and reports improvements in skin and wound healing but notes a need for further study to fully understand these mechanisms.

This observational study found that a high-dose biotin regimen of 10,000 mcg/day reduced hair loss and improved hair and scalp conditions in female patients with androgenic alopecia, with effects lasting beyond treatment discontinuation, warranting further investigation into biotin's role in combination therapy.

In this study, biotin supplementation was found to significantly increase wool follicle viability and metabolic activity in vitro, with the highest effects observed at 0.5 mg L⁻¹ concentration.

This study found that a newly produced version of KGF-1 with 135 residues maintained biological activity and could serve as an alternative to the standard 140-residue KGF-1.

This article discusses the importance of considering biotinidase deficiency in differential diagnosis for patients with certain neurological and dermatological symptoms, as timely treatment with biotin is crucial to prevent severe consequences.

In this case study, biotin supplementation was reported to interfere with free testosterone assay results, leading to falsely low readings in a postmenopausal woman with hyperandrogenism.

This study explored the effects of biotin and malate supplementation on hair follicle viability and enzyme activity in cultured cells, but it reports no new results.

This review discusses the role of biotin in enzyme function and its effects on hair, skin, and nail health, noting that significant improvements are mostly seen in people with biotin deficiency, and reports no new clinical results.

This case report describes a 10-month-old boy with dermatitis, alopecia, and hypotonia who showed dramatic improvement with oral biotin, suggesting a possible defect in biotin absorption or transport.

In this study, oral biotin improved hair growth, strength, and combability in a child with uncombable hair syndrome, while hair in two others slowly improved without biotin.

This study found that a 671-base pair promoter sequence from the ultra-high-sulfur keratin gene is sufficient to direct tissue-specific and development-specific expression of a reporter gene during hair growth in transgenic mice.

This study found that biotin supplementation improved biotinidase activity and led to clinical remission in some patients with alopecia areata.

In this animal study, applying a combination of inositol-stabilized arginine silicate complex and magnesium biotinate promoted hair growth but not nail growth.

This article reviews the potential benefits of GHK-Cu, EAA, and water-soluble propolis for wound healing, skin tightening, and anti-aging effects, but reports no new clinical results.

In this study, water-soluble recombinant keratins, specifically RK81, were developed and used in microneedles to investigate their effect on hair growth, discovering that more than 40% of the hair follicles responded, demonstrating the potential for hair growth promotion.

This case report describes a 2-month-old male with biotinidase deficiency whose seizures and skin symptoms improved dramatically with oral biotin supplementation.

This study presents recombinant human hair keratins K31 and K81, observing novel nanostructures from their self-assembly and emphasizing disulfide crosslinking's role in this process.

In this study, the researchers observed that biotin administration in biotin-deficient children with alopecia eliminated certain membrane proteins from their blood, suggesting that biotin might regulate these proteins' expression.

This article discusses the social popularity versus clinical efficacy of biotin supplementation for hair loss and reports no new results; it highlights the need to address media-driven myths.

This study demonstrated that vitamin B12 may promote hair growth in vitro by modulating intracellular signaling in the wnt-pathway, suggesting potential benefits for micrograft transplantation.

This study demonstrates that the amino-terminally shortened KGF-1 variant with 135 residues maintains biological activity, suggesting it may serve as an alternative to the original KGF-1 for certain therapeutic applications.

This case report describes a 5-year-old girl with biotinidase deficiency who had acute visual loss and gait disturbance but no typical symptoms, responding well to biotin therapy.

This review provides an overview of biotin's role in metabolism and the consequences of deficiency but reports no new clinical findings; it highlights that intestinal bacteria usually meet biotin needs.

This research reports that the ultra-high sulfur keratin promoter acts as a tissue-specific promoter in mouse hair follicles, as shown by induced expression of GFP and β-gal in that region post-transfection.

This study found that HMGB1 enhanced hair growth by stimulating PGE2 production in human dermal papilla cells, suggesting a potential therapeutic target for alopecia treatment.