The Influence of Biotin on Viability, Pyruvate Carboxylase Activity and the Response to Malate Concentration In Vitro by Isolated Secondary Hair Follicles of the Angora Goat

    January 1999 in “ Proceedings of the British Society of Animal Science ”
    A.M. Tahmasbi, H. Galbraith, J. R. Scaife
    TLDR Biotin deficiency may harm hair follicle health and growth in Angora goats.
    The study investigated the effects of biotin on the viability and pyruvate carboxylase activity of isolated secondary hair follicles from Angora goats. Biotin, essential for certain carboxylation reactions, was hypothesized to influence hair follicle growth due to its role in pyruvate carboxylase activity, which is crucial for oxaloacetate production in metabolism. The research aimed to assess how biotin supplementation affected hair follicle viability and enzyme activity, as well as the impact of malate supplementation, which could alter oxaloacetate demand. The findings suggested that biotin deficiency might reduce pyruvate carboxylase activity, potentially affecting hair follicle growth.
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