Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study presents computational modeling and experimental analysis of the HGT protein KAP8.1, identifying key structural features that may influence hair's response to environmental conditions.

This study found that early biochemical screening and molecular confirmation are crucial for distinguishing profound from partial biotinidase deficiency, which supports timely treatment and management in symptomatic children.

This study presents a method using liquid chromatography tandem mass spectrometry to quantify biotin in plasma and serum, and explores how high biotin intake can interfere with diagnostic immunoassays that utilize biotin-streptavidin technology, potentially leading to misdiagnosis of endocrine disorders.

This study highlights that the popular marketing of biotin for hair loss treatment in healthy individuals lacks scientific support, as evidenced by a review of relevant clinical trials.

This research provides insights into how keratin hydrogels, modified to control disulfide crosslinking, may function as a treatment platform for bone injuries.

This review discusses biotin's role in nutrition and suggests no benefit to supplementing it for hair, nails, and skin in healthy individuals; it reports preliminary findings that high dosages may help some multiple sclerosis patients.

This summary outlines the essential roles and recommended daily intakes of biotin, while discussing consequences and mechanisms of deficiency, but presents no new research findings.

This study examined the role of biotin deficiency and adequacy on cell proliferation and DNA synthesis in isolated mohair follicles.

This research reports that KCV and its palmitoylated derivatives show strong effectiveness in strengthening hair proteins, indicating their potential for use in advanced hair care products.

This review discusses biotin supplementation for dermatological conditions and highlights the lack of strong evidence supporting its efficacy, as well as the potential for laboratory testing interference.

This case report describes an 11-month-old infant with Biotinidase deficiency who exhibited multifocal seizures, neuroregression, alopecia, and skin issues, highlighting prompt diagnosis and the dramatic clinical response to biotin treatment.

This study found that germ-free mice on a biotin-deficient diet exhibited significant weight loss and severe alopecia, unlike conventional mice on the same diet.

In their review, the authors found no strong evidence supporting biotin's effectiveness as a hair supplement, noting a significant disparity between its popularity and scientific backing, with available studies showing no substantial benefit over placebo.

This case study reports a two and a half-month-old with biotinidase deficiency who showed rapid seizure improvement with biotin treatment after presenting with convulsions and neurological symptoms.

In this animal study, the ketogenic diet was associated with more severe biotin deficiency in biotin-deficient mice, suggesting that biotin supplementation is important when following this diet.

This study identified that biotin ingestion led to interference in immunoassay results, falsely indicating high testosterone and insulin levels in a 28-year-old female patient, thus complicating her clinical assessment and treatment planning until recognized and resolved.

This review discusses biotinidase deficiency, noting that biotin treatment from birth can prevent symptoms, but acknowledges the complexity and need for further understanding due to late-onset cases with varied clinical findings.

This case report illustrates that high-dose biotin supplementation can cause false thyroid function test abnormalities in vitro, emphasizing the need to assess biotin intake before testing.

This study found that biotin supplementation is common among patients at a dermatology clinic despite a lack of evidence for its dermatologic benefits and potential interference with lab tests.

This study found no conclusive evidence of biocatalytic activity of guinea pig liver transglutaminase with virgin human hair, potentially due to a fatty acid layer on the hair surface.

This study suggests that biotin therapy may be beneficial for individuals with partial biotinidase deficiency, as some developed symptoms later, which resolved with treatment.

The researchers characterized a plant-based biotin supplement, SesZenBioTM, from Sesbania agati leaves, predicting it may enhance hair follicle growth more effectively than synthetic biotin based on molecular interactions and its biotin content.

This study found that both GHK-Cu liposome and GHK-Cu promoted hair growth and increased VEGF expression in a mouse model of alopecia.

This study reports the cloning and sequencing of two type II hair-specific keratin genes, ghHb1 and ghHb6, located on chromosome 12q13, which are expressed during hair growth.

This research found that the transfer reaction catalyzed by human plasma and guinea pig hair follicle transglutaminases aligns with a ping-pong mechanism involving peptide-bound glutamine.

This review discusses the role of biotin in metabolism and its dietary requirements, but provides no new experimental findings.