5 citations
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May 2019 in “Cureus” In this study, the authors reported that taking 20 mg or more of biotin can interfere with thyroid function tests, potentially leading to false diagnoses of conditions like Grave's disease.
November 2022 in “Journal of the Endocrine Society” In this case study, biotin supplementation was reported to interfere with free testosterone assay results, leading to falsely low readings in a postmenopausal woman with hyperandrogenism.
115 citations
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May 2016 in “Clinical Medicine & Research” This review discusses the complexities of interpreting thyroid function tests, highlighting the challenges primary care providers face due to patient demand and misinformation, but reports no new results.
January 2021 in “Scandinavian journal of clinical and laboratory investigation” This study presents a method using liquid chromatography tandem mass spectrometry to quantify biotin in plasma and serum, and explores how high biotin intake can interfere with diagnostic immunoassays that utilize biotin-streptavidin technology, potentially leading to misdiagnosis of endocrine disorders.
October 2024 in “Journal of the Endocrine Society” This case report highlights that macro-TSH, a rare condition causing falsely elevated TSH despite normal thyroid hormone levels, can lead to misdiagnosis and unnecessary treatment; identifying TSH antibodies and fractionation chromatography can prevent incorrect management, as demonstrated in a 19-year-old patient.