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The conclusion is that accurately replicating the complexity of the extracellular matrix in the lab is crucial for creating realistic human tissue models.

Plant-based compounds might be effective, low-side-effect treatments for prostate cancer by blocking a specific enzyme.

Plant adaptogens may help treat skin diseases and improve skin health, but more research is needed to fully understand how they work.

Minoxidil activates hair growth by being sulfated by P-PST in the human liver.

GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

The document concludes that the human keratin gene cluster is complex, with a need for updated naming to reflect over 50 functional genes important for hair and skin biology.

Male and female skin differ in many ways, which could lead to gender-specific skin treatments.

Pyrene excimer nucleic acid probes are promising for detecting biomolecules accurately with potential for biological research and drug screening.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Minoxidil breakdown varies by enzymes, affecting hair loss treatment effectiveness.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Levetiracetam is widely used and generally well-tolerated for treating idiopathic generalized epilepsies, with tiredness as the main side effect.

Human head hair proteins can be typed into eight distinct patterns, useful for genetic and forensic investigations.

The enzyme type 1 5α-reductase is more active in the hair follicle's lower part than in the skin's outer layer.

Scientists made new substances that can block an enzyme linked to prostate issues and hair loss, with potential for creating a new treatment.

Keratin hydrogels from human hair show promise for tissue engineering and regenerative medicine.

Coumarin derivatives show promise as anti-estrogenic agents for treating breast cancer, with some in clinical trials.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

The study found that two enzymes linked to hair loss are located in different parts of the scalp, supporting a common treatment's effectiveness.

Growth factors are crucial for hair development and could help treat hair diseases.

Advancements in creating skin grafts with biomaterials and stem cells are promising, but more research is needed for clinical application.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

The skin's basement membrane has specialized structures and molecules for different tissue interactions, important for hair growth and attachment.

PNU157706 reduced rat sperm movement and fertility without affecting offspring health.

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.