114 citations
,
November 2022 in “Biomedicine & Pharmacotherapy” This review discusses current wound management strategies and examines electrospun nanofibers with biological macromolecules for their potential in tissue engineering and drug delivery, but reports no new clinical results.
110 citations
,
February 2024 in “Journal of Chemical Information and Modeling” This study describes the PandaOmics platform, which uses AI and bioinformatics to identify new therapeutic targets and biomarkers for various diseases, demonstrating validation in laboratory and animal studies.
101 citations
,
July 1985 in “Journal of the American Academy of Dermatology” In this study, oral biotin improved hair growth, strength, and combability in a child with uncombable hair syndrome, while hair in two others slowly improved without biotin.
99 citations
,
May 1998 in “Journal of biological chemistry/The Journal of biological chemistry” This study found that small proline-rich proteins modify the biomechanical properties of cornified cell envelopes in rodent forestomachs, potentially affecting the tissue's ability to withstand mechanical stress.
91 citations
,
December 2017 in “Systems Biology in Reproductive Medicine” This meta-analysis found that lower serum SHBG levels are associated with an increased risk of PCOS, and improving SHBG levels through treatment may reduce PCOS complications.
90 citations
,
July 2014 in “Conservation Physiology” This study found that hair cortisol concentration in free-ranging brown bears is influenced by handling methods, body condition, and potentially both short- and long-term stressors.
89 citations
,
January 2021 in “Molecules” This review discusses the applications of biopolymeric composites in controlled drug release, tissue engineering, and wound healing, but reports no new experimental results, highlighting the need for further development and analysis.
89 citations
,
January 2020 in “PubMed” This review discusses biotinidase deficiency, noting that biotin treatment from birth can prevent symptoms, but acknowledges the complexity and need for further understanding due to late-onset cases with varied clinical findings.
89 citations
,
September 2010 in “Annual Review of Genomics and Human Genetics” This review discusses the genetic factors involved in hair follicle morphogenesis and cycling and reports no new clinical results; it emphasizes the role of genes in hereditary hair diseases.
89 citations
,
October 2003 in “Biology of the Cell” This study found that labeled galectin-1 binds to specific nuclear sites in human bone marrow stromal cells and keratinocytes, suggesting a role in nuclear function, although only in a small fraction of cells.
88 citations
,
December 2018 in “Advanced Healthcare Materials” This review outlines the current state and future prospects of using layer-by-layer self-assembly for cell encapsulation in biomedical applications, such as cell-based biosensors, transplantation, and tissue engineering, while also discussing its limitations and potential advancements.
87 citations
,
August 2017 in “Scientific Reports” This study found that PCL-based nanofiber scaffolds enhanced cell proliferation and extracellular matrix deposition, suggesting they show promise as a cell delivery system for improving skin wound healing.
86 citations
,
January 1990 in “The Journal of Pediatrics” This study suggests that biotin therapy may be beneficial for individuals with partial biotinidase deficiency, as some developed symptoms later, which resolved with treatment.
85 citations
,
June 2022 in “Cellular and Molecular Life Sciences” 85 citations
,
August 2021 in “Materials & Design” This review summarizes advancements in biomaterial-based encapsulation of probiotics for diverse biomedical uses and reports no new clinical results, while outlining current challenges and future research directions.
83 citations
,
June 2020 in “Materials & Design” In this study, ACF sponges with 10% fucoidan significantly promoted wound healing and hair follicle regeneration in rats, showing improved hemostatic and antibacterial performance compared to other formulations.
83 citations
,
May 2021 in “Biomolecules” This study found that an injectable composite hydrogel containing cerium bioactive glass improved wound healing in diabetic rats by promoting angiogenesis and offering antibacterial properties, suggesting its potential for enhancing diabetic foot wound repair.
82 citations
,
July 2022 in “Bioengineering & Translational Medicine” This review examines how biochemical and biophysical induction factors influence cell fate in tissue engineering and reports no new experimental results.
82 citations
,
January 2022 in “Bioactive Materials” This review discusses extrusion-based bioprinting bioinks for skin regeneration, highlighting their current applications, limitations, and potential improvements, but reports no new experimental findings.
82 citations
,
August 2017 in “Cell Reports” This study found that antibiotic-induced gut dysbiosis, particularly overgrowth of Lactobacillus murinus, can lead to hair loss in mice by depleting biotin.
82 citations
,
January 1997 in “Forensic science international” This article presents a biochemical model to explain how drug molecules are incorporated into hair, highlighting factors such as drug melanin affinity and the role of physico-chemical properties.
82 citations
,
October 1980 in “The Journal of Clinical Endocrinology & Metabolism” This case study describes a child with an unusual form of vitamin D-dependent rickets, characterized by alopecia and a deficient response to active vitamin D.
81 citations
,
October 2023 in “Bioactive Materials” This review highlights the promising potential of 3D printing for creating microneedles with precise customization and improved performance compared to traditional micromolding, emphasizing applications in personalized medical devices and advancements in biomedical fields.
81 citations
,
March 2022 in “Frontiers in Bioengineering and Biotechnology” This review discusses advancements and challenges in bioengineered scaffolds for wound healing but presents no new experimental findings, highlighting their potential and need for further development.
79 citations
,
January 2015 in “Journal of Materials Chemistry B” This review discusses the development and future prospects of biomaterials for in situ tissue regeneration but reports no new research results; it underscores the importance of biomaterials in addressing tissue defects.
78 citations
,
January 2017 in “Skin appendage disorders” This review discusses the use of biotin for hair and nail growth, noting clinical improvement in cases with existing pathologies, but concludes there is insufficient evidence supporting its benefits for healthy individuals.
77 citations
,
April 2016 in “Science Advances” Researchers created a fully functional, bioengineered skin system with hair from stem cells that successfully integrated when transplanted into mice.
74 citations
,
July 1979 in “Lancet” This case report describes a 10-month-old boy with dermatitis, alopecia, and hypotonia who showed dramatic improvement with oral biotin, suggesting a possible defect in biotin absorption or transport.
73 citations
,
October 2003 in “Journal of Pharmacology and Experimental Therapeutics” This study found that hair depigmentation in mice and humans can be a dynamic indicator of KIT inhibition by the drug SU11248, correlating with treatment periods.
73 citations
,
October 2001 in “Epilepsia” In this study, valproic acid treatment was associated with reduced biotinidase activity and improved skin lesions after biotin supplementation in children with seizures.