February 2025 in “BMC Veterinary Research” This study examined proteomic changes in Inner Mongolia cashmere goat skin, finding 631 proteins differentially regulated during hair growth stages; key keratin proteins, crucial for hair follicle development, were localized in secondary hair follicles.
July 2023 in “Current Issues in Molecular Biology” This study found that escin acts as a natural agonist of the Wnt/β-catenin signaling pathway in cultured human dermal papilla cells by promoting the degradation of GSK-3β, highlighting its potential therapeutic use for conditions like androgenetic alopecia and vitiligo.
May 2023 in “Frontiers in Endocrinology” This study found that tildacerfont treatment in males with congenital adrenal hyperplasia reduced androgen levels and improved markers of testicular function, suggesting potential benefits for male reproductive health.
19 citations
,
April 2018 in “Clinical cardiology” This study found that among older men, low levels of free dihydrotestosterone were associated with an increased risk of developing atrial fibrillation.
14 citations
,
November 2012 in “SLAS discovery” This study observed that certain herbal extracts may promote hair growth and inhibit hair loss in cell lines by affecting specific protein expressions similarly to minoxidil.
12 citations
,
July 2020 in “DOAJ (DOAJ: Directory of Open Access Journals)” This review evaluates the hormonal, metabolic, and clinical aspects of a male equivalent PCOS syndrome in men and highlights areas where further research is needed, reporting no new empirical findings.
7 citations
,
February 2017 in “The American journal of medicine” This case report describes a 34-year-old woman who, after Roux-en-Y gastric bypass surgery, experienced improvements in symptoms of dizziness and energy following treatment with oral ferrous sulfate for iron deficiency.
September 2023 in “Clinical, Cosmetic and Investigational Dermatology” This study found a significant negative correlation between serum SHBG levels and androgenetic alopecia severity in women, but not in men, while no significant correlation was observed for testosterone, estradiol, dehydroepiandrosterone sulfate, and vitamin D levels with hair loss severity across genders.
July 2015 in “Egyptian Journal of Dermatology and Venereology” This study concluded that patients with androgenetic alopecia may have a higher risk of cardiovascular diseases compared to people without this condition.
9 citations
,
January 1992 in “Journal of Investigative Dermatology” This study found distinct differences in UEA I glycoprotein binding on follicular keratinocytes between anagen and telogen hair follicles, with staining associated with follicle length and regrowth.
23 citations
,
February 1979 in “Veterinary Clinics of North America: Small Animal Practice” This review discusses the physicochemical properties, binding mechanisms, and factors affecting corticosteroid-binding globulin (CBG) functions, but reports no new clinical results.
14 citations
,
November 2014 in “European journal of medicinal chemistry” This study identified 30 new compounds with significant androgen receptor binding affinity through a combination of virtual screening and in vitro testing.
January 2006 in “Carl von Ossiezky University of Oldenburg” This study observed that unpigmented keratinocytes saturate quickly with foreign substance uptake compared to pigmented melanocytes, where melanin significantly enhances binding.
5 citations
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February 2016 in “Genetic Testing and Molecular Biomarkers” This study found that the expression levels of nucleolin, nucleophosmin, and UBTF genes were lower in normal sites compared to hair loss sites in males with alopecia.
May 2021 in “Letters in Applied NanoBioScience” This study used computational methods to identify pranlukast and mirabegron as promising candidates for repurposing against diabetes due to their good binding interactions with the DPP-IV target.
21 citations
,
February 2017 in “Dermatologic surgery” In this study, different donor and recipient site preparation techniques for melanocyte-keratinocyte suspension were associated with similar repigmentation outcomes in stable vitiligo, but efficacy varied by body site.
122 citations
,
July 2005 in “The FASEB journal” This study found that hair follicles in both mice and humans may serve as an important site for melatonin synthesis and signaling, potentially influencing hair cycle regulation by modulating keratinocyte apoptosis.
67 citations
,
January 2022 in “Theranostics” This review highlights how advanced nanocarrier and microneedle-based transdermal drug delivery strategies can potentially improve the treatment of skin diseases by enhancing site-specific drug delivery, increasing skin penetration, and reducing systemic toxicity compared to conventional methods.
14 citations
,
February 2018 in “Psychoneuroendocrinology” This study found that male 5α-reductase 2 knockout mice showed deficits in social dominance behaviors and reduced dopamine receptor binding in a brain region related to social ranking.
9 citations
,
March 1991 in “Endocrinology” This study in rats suggests that combining the 5 alpha-reductase inhibitor 4-MA with the antiandrogen Flutamide may enhance prostate cancer therapy by additively inhibiting prostatic growth and mRNA levels of androgen-sensitive prostatic binding proteins.
January 2024 in “Journal of Applied Pharmaceutical Science” This study identified procyanidin B2 and leucopelargonidin from Saraca asoca as potential inhibitors in PCOS by showing high binding energy scores against key enzymes involved in estrogen and testosterone biosynthesis.
September 2017 in “Journal of Investigative Dermatology” This study suggests that the newly characterized sebocytic progenitor cells HSGC1 and HSGC2 from different skin sites may have proliferative and differentiating potential in response to DHT.
2 citations
,
July 2025 in “Discover Chemistry.” This study explored the optimization of phytochemicals from Alstonia boonei to develop potential 5-alpha reductase inhibitors for Benign Prostatic Hyperplasia, finding promising analogs with enhanced binding affinity and stability compared to Finasteride, warranting further experimental validation.
June 2020 in “Journal of cosmetic medicine” This abstract reviews eyebrow transplantation techniques, highlighting that follicular unit extraction prevents scarring at the donor site, unlike strip harvesting, and reports no new clinical results.
25 citations
,
August 2014 in “Endocrinology” This study created a humanized mouse model of hereditary vitamin D-resistant rickets that lacks alopecia, indicating the mutant receptor's potential to explore the syndrome's characteristics beyond vitamin D binding.
4 citations
,
September 2024 in “Jurnal Pengolahan Hasil Perikanan Indonesia” In this study, researchers reported that compounds from Bruguiera gymnorhiza leaves showed anti-inflammatory potential in in silico analyses, with favorable drug properties and specific binding to the IKKβ receptor, suggesting possible development into anti-inflammatory drugs.
1 citations
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September 2022 in “Sudan Journal of Medical Sciences” This molecular docking study reported that danoprevir, remdesivir, and saridegib exhibit stronger binding affinities to the main protease of SARS-CoV-2 than the control, suggesting their potential as inhibitors of the virus's replication process.
48 citations
,
May 2023 in “Nature Communications” In a study on muscle regeneration in mice, researchers found that platelet-secreted CXCL7 is crucial for recruiting neutrophils to injury sites, aiding early muscle repair and optimal regrowth, suggesting potential therapeutic uses for boosting muscle healing.
24 citations
,
May 2019 in “PLOS ONE” In this study, researchers observed that African spiny mice, Acomys cahirinus, are capable of regenerating skeletal muscle in dermal wound sites, unlike common mice, Mus musculus.
15 citations
,
January 2012 in “Journal of Veterinary Science” This study examined variations in epidermal thickness and protein expression across different dog breeds, finding significant differences by anatomical site and breed, with associated mRNA and protein expression changes observed.