In-Silico Screening of Potential Anti-Androgenic and Anti-Estrogenic Phytocompounds from Saraca Asoca for Polycystic Ovary Syndrome Treatment

This study investigates the potential of phytocompounds from Saraca asoca for treating polycystic ovary syndrome (PCOS) by targeting the ovarian steroidogenesis pathway. Using in-silico methods, 56 ligands were analyzed for their binding affinity to key enzymes and receptors involved in hormone production. Procyanidin B2 and leucopelargonidin showed the highest docking scores, indicating strong potential as inhibitors of aromatase and 17-HSD1, which are involved in estrogen and testosterone biosynthesis. The top seven compounds, including procyanidin B2 and leucopelargonidin, met drug-likeness criteria and demonstrated favorable chemical and biological reactivity, suggesting their promise as treatments for hormonal imbalance in PCOS.