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Scientists found gene mutations that affect hair loss, skin stem cells, and skin disorders, and identified drugs that may help treat blood vessel and skin conditions.

The Hairless gene is crucial for healthy skin and hair growth.

Skin's uneven surface and hair follicles affect its stress and strain but don't change its overall strength, and help prevent the skin from peeling apart.

The 3D-SeboSkin model effectively simulates Hidradenitis suppurativa and is useful for future research.

Dermal Papilla Cells grown in 3D and with stem cells better mimic natural hair growth conditions than cells grown in 2D.

The vitamin D receptor is involved in multiple body functions beyond calcium regulation, including immune response and rapid reactions not related to gene activity.

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.

Understanding phenotypic plasticity is crucial for developing effective cancer therapies.

β-catenin is essential for stem cell activation and proliferation in hair follicles.

The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.

Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.

Videodermoscopy improves diagnosis of hair and scalp disorders and may reduce scalp biopsies.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.

The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.

Women with PCOS are more likely to have impaired glucose tolerance and type 2 diabetes, especially if they are Asian or obese.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Shorter CAG repeats may cause hair and skin issues, while longer ones may link to acne.

ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.

Jumonji genes are important for development and their mutations can cause abnormalities, especially in the heart and brain.

Early development of hair, teeth, and glands involves specific signaling pathways and cellular interactions.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

The dermal papilla is crucial for hair growth and health, and understanding it could lead to new hair loss treatments.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Keratose, derived from human hair, is a non-toxic biomaterial good for tissue regeneration and integrates well with body tissues.