2 citations
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January 2026 in “Frontiers in Endocrinology” This review discusses the impaired functionality of regulatory T cells in the pancreas during the development of Type 1 diabetes, highlighting their role in disease pathogenesis, potential of Treg-based therapies, and challenges in clinical applications.
October 2022 in “Journal of Pharmaceutical Negative Results” This review examines the therapeutic effects of photobiomodulation on severe medical illnesses but reports no new clinical results; it emphasizes its potential in neurology, pulmonology, inflammation, dermatology, wound healing, and oncology.
1057 citations
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November 2011 in “Annals of Biomedical Engineering” This review discusses the applications of low level laser therapy (LLLT) in wound healing, pain reduction, and treating various conditions, but reports no new clinical results; the authors highlight the need for randomized controlled trials for serious diseases.
105 citations
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February 1996 in “Journal of biological chemistry/The Journal of biological chemistry” In this study, sequences upstream of the TGM3 gene were found to regulate epithelial-specific gene expression in keratinocytes, suggesting potential applications in gene therapy.
93 citations
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May 2002 in “Journal of Investigative Dermatology” This study found that chronic ultraviolet-B exposure increased skin vascularization and wrinkle formation in mice, while overexpressing the angiogenesis inhibitor thrombospondin-1 reduced these effects, suggesting angiogenesis inhibition as a potential approach to prevent photo-damage.
65 citations
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August 2013 in “Acta Biomaterialia” This study suggests that a novel micropatterned dermal–epidermal matrix (μDERM) enhances keratinocyte function and epidermal morphology, offering potential improvements in skin substitute design for wound healing applications.
58 citations
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December 2018 in “Nature Communications” This study found that male pattern baldness in European males is strongly heritable and associated with genetic markers linked to earlier puberty, bone density, and pancreatic function.
21 citations
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January 2023 in “International Journal of Molecular Sciences” This review discusses the role and interactions of the calcium-binding protein S100A6 in cellular processes and its association with various diseases, highlighting the need for further research to fully understand its biological impact.
17 citations
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September 2016 in “Stem cells translational medicine” In this study, using stirred-suspension bioreactors to expand dermal stem cells resulted in larger numbers, but had reduced efficiency in forming hair follicle structures compared to static culture conditions.
14 citations
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January 2006 in “Skin pharmacology and physiology” This study found that procyanidin oligomers from apples and barley may stimulate hair growth by promoting hair epithelial cell proliferation and protecting them from apoptosis via MEK activation in a murine model.
14 citations
,
January 1985 in “International Journal of Dermatology” The cause of alopecia areata was unknown, and while various treatments existed, no best treatment was agreed upon.
3 citations
,
July 2023 in “Biomolecules” This study reports that some human cell surface HLA-I molecules (including HLA-B27) can appear without their usual peptide component, potentially altering immune interactions, influencing arthritis development in specific mice models, and exhibiting upregulation in certain cancer cells.
1 citations
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September 2025 in “Frontiers in Immunology” This study found that FRβ knockout mice exhibited autoimmune symptoms and slower tumor growth compared to wild type mice, suggesting that the FRβ receptor may play a role in regulating immune responses in tumors and autoimmune conditions.
April 2025 in “Journal of Biophotonics” This study found that 808 nm laser photobiomodulation altered mitochondrial respiration and enhanced osteogenic protein expression in human dental pulp stem cells, with the effects being dose-specific and more pronounced at 15 J/cm².
13 citations
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October 2021 in “International Journal of Molecular Sciences” In this study, an immortalized MSC line from human adipose tissue showed potential for applications in regenerative medicine and inflammatory diseases through production of active factors, demonstrated in vitro.
113 citations
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June 2015 in “Stem Cell Research & Therapy” This study found that activation or inhibition of Wnt/β-catenin and Notch signaling pathways in rats can alter wound healing, possibly by affecting epidermal stem cell activity and keratinocyte behavior.
55 citations
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October 2015 in “Journal of Investigative Dermatology” Alopecia areata is linked to immune-related genes, suggesting JAK inhibitors as a potential treatment.
53 citations
,
April 2016 in “Stem cell research & therapy” This study reports that LL-37 treatment enhances cell proliferation, migration, and secretion of regenerative factors in adipose-derived stem cells, potentially promoting hair growth in vivo.
32 citations
,
April 2020 in “BMC Developmental Biology” This study found that ocu-miR-205 influences hair follicle density and signaling pathways in Rex rabbits by promoting dermal papilla cell apoptosis and altering hair follicle phases.
20 citations
,
October 2021 in “PLoS ONE” This study found significant differences in gene expression between newborn and adult skin, with infant skin notably increasing processes related to ECM organization, cell adhesion, and collagen fibril organization.
16 citations
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April 2021 in “International Journal of Molecular Sciences” This study found that micro-current electrical stimulation may promote hair growth in human hair follicle-derived papilla cells and a mice model by enhancing cell proliferation, migration, and activating key growth pathways.
6 citations
,
June 2017 in “Asian journal of beauty & cosmetology” In this study, Rosa multiflora root extracts showed strong antioxidant activity and promoted expression of growth factors IGF1 and PDGFB, suggesting potential use as a natural hair growth agent.
5 citations
,
October 2022 in “Cosmetics” This article reviews in-vitro and cell-free methods for assessing the efficacy of herbal ingredients in cosmetic formulations for skin health and hair growth, but it reports no new clinical results.
5 citations
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October 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified a high-risk allele in the PLCD1 gene associated with hereditary trichilemmal cyst formation, proposing a monoallelic two-hit mechanism as the underlying genetic pathogenesis.
2 citations
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May 2023 in “Frontiers in Bioengineering and Biotechnology” This review explores the potential of multifunctional bioscaffolds in skin tissue engineering, highlighting their successful biological performance in vitro and in vivo animal models, while also identifying the demand for technological advancements to improve wound healing applications in clinical settings.
1 citations
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December 2015 in “The Egyptian Journal of Histology” This study found that experimentally induced hypothyroidism in rats is associated with impaired skin structure, but topical application of triiodothyronine (T3) improved these changes to resemble normal skin.
February 2025 in “Stem Cell Research & Therapy” This study reviews advancements in hair follicle regeneration, discussing the benefits and limitations of methods such as organ germ assembling, stem cell induction, and bioprinting, while highlighting the challenges of replicating embryonic signals and finding suitable cell sources for clinical applications.
June 2023 in “Research Square (Research Square)” This study found that polycaprolactone (PCL) in facial fillers led to more cell proliferation and vascular activity than hyaluronic acid (HA) in Wistar rats, suggesting enhanced tissue regeneration effects with PCL.
August 2020 in “Current psychopharmacology” In this study, neurotrophic factors, synaptic plasticity, and neurogenesis changed in the hippocampus of rats during pregnancy, lactation, and pup deprivation, potentially influencing maternal care.
53 citations
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August 2019 in “American journal of human genetics” This study found that FOXN1 haploinsufficiency is a significant genetic factor causing T cell lymphopenia at birth, linked to reduced thymic function in both humans and mice.