October 2023 in “Pediatric dermatology” This study found that Middle Eastern patients with epidermolysis bullosa show specific correlations between their genetic variants and clinical features, which may aid in diagnosis and genetic counseling.
87 citations
,
November 2002 in “Journal of Investigative Dermatology”
58 citations
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June 2018 in “Scientific reports” This study identified novel genetic associations with skin phenotypes such as age-spots, freckles, and hair characteristics in Japanese women, providing insights into the genetic basis of these traits.
February 2024 in “Veterinary sciences” This study found that canine pemphigus foliaceus skin lesions exhibit a distinct immune signature, with upregulated pro-inflammatory and Th17-related genes, showing similarities to human pemphigus. Further research using advanced sequencing is needed to better understand the disease's pathogenesis.
23 citations
,
November 2020 in “Central-European Journal of Immunology/Central European Journal of Immunology” This review explores the autoimmune hypothesis of alopecia areata and the possible genetic and melanogenesis-associated autoantigens, but reports no new clinical findings.
July 2025 in “Journal of Investigative Dermatology” 22 citations
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July 1998 in “Journal of Investigative Dermatology” This study identified and characterized a gene called 4C32, which is expressed in the periderm of embryonic mouse skin and has a structure similar to keratin-associated proteins.
14 citations
,
February 2022 in “The Journal of clinical investigation/The journal of clinical investigation” This study found that the development of Merkel cell carcinoma from hair follicles in mice can be driven by in vivo reprogramming with ATOH1 and relies on p53 loss for progression.
17 citations
,
July 2024 in “Frontiers in Oncology” This review discusses recent advances in understanding Merkel cell carcinoma biology, including the development of genetically-engineered mouse models and potential therapeutic targets, but reports no new clinical results.
July 2026 in “Journal of Investigative Dermatology” 482 citations
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June 1979 in “Proceedings of the National Academy of Sciences” This study demonstrated that keratin is widely present in various epithelial cells, providing structural strength and potential insights into the origin of cell lines.
May 2025 in “Galen Medical Journal” This research highlights advancements in understanding and treating psoriasis, finding that targeted therapies like IL-17 and IL-23 inhibitors show promise, but challenges such as adverse events, treatment resistance, and the need for personalized approaches remain.
26 citations
,
July 2012 in “Biochimica et Biophysica Acta (BBA) - General Subjects” This review discusses the identification and roles of different epidermal stem cell types in skin homeostasis and repair, and reports no new experimental findings.
5 citations
,
June 2015 in “The Journal of Dermatology” This study identified "HTLV-1-associated lichenoid dermatitis" as a skin condition in HTLV-1-infected individuals, characterized by reactive eruptions associated with increased immunity toward infected CD4+ T cells.
4 citations
,
November 2018 in “Journal of comparative pathology” This study found that adipokines were expressed in the epidermis, hair follicles, sebocytes, apocrine glands, and vascular endothelium of normal canine skin, but not in the dermis or hypodermis.
August 2025 in “Annals of the Rheumatic Diseases” This study observed that the relationships between various criteria used to classify systemic lupus erythematosus are more consistent with chance than predictable patterns, although connections within the same organ domain are relevant.
51 citations
,
February 2004 in “Journal of Investigative Dermatology” MCSP may help identify and regulate skin stem cells, affecting hair growth and regeneration.
137 citations
,
October 2009 in “The American journal of pathology” This study found that matriptase, a membrane serine protease, is crucial for maintaining multiple types of epithelial tissues in mice, with its absence leading to severe organ dysfunction and increased permeability.
80 citations
,
June 1997 in “The American Journal of Human Genetics” 20 citations
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July 1987 in “Development Genes and Evolution”
28 citations
,
January 2013 in “Stem cells” This study found that the CD44(+) ALDH(+) population of neonatal human keratinocytes exhibited enhanced stem cell properties, including significantly increased long-term epidermal regeneration and multipotency, compared to unfractionated cells.
13 citations
,
May 2001 in “Current problems in dermatology” Keratin proteins in epithelial cells are dynamic and crucial for cell processes and disease understanding.
September 2017 in “Pediatric Dermatology” The document concludes that an experimental drug may help wound healing in Epidermolysis Bullosa, links Hydroa vacciniforme to EBV, discusses diagnosing hair loss disorders, finds many children with eczema have allergies, reviews the safety of a skin medication in children, notes side effects of a Duchenne's treatment, and identifies a marker for pediatric mastocytosis.
January 2026 in “Biocell” This review discusses the potential of gut microbiota-derived exosomes as drug delivery systems and reports no new clinical results; the authors highlight their promise for precision medicine.
January 2023 in “Discovery immunology” T cells and bacteria in the gut and skin help maintain health and protect against disease.
76 citations
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May 2011 in “Cell death and differentiation” This study found that the enzyme A20 helps regulate EDAR-induced NF-κB signaling in mice, preventing ectodermal abnormalities like disheveled hair and assuring proper skin and appendage development.
January 2026 in “Immunity & Inflammation” This review discusses a "stochastic multi-hit model" to explain the onset, progression, and recurrence of vitiligo and other autoimmune skin diseases, emphasizing genetic and environmental influences, immune cell interactions, and unexplored mechanistic gaps.
6 citations
,
November 2008 in “Journal of Dermatological Science” Certain proteins involved in DNA modification may affect the genetic changes in systemic lupus erythematosus and could indicate the disease's activity.
9 citations
,
January 1990 in “Skin Pharmacology and Physiology” This study observed that 67 kDa keratin was expressed homogeneously only in epidermis derived from hair follicle explants, differing from other culture methods where expression was delayed and patchy.
February 2013 in “Journal of the American Academy of Dermatology” In this study, the HairCheck device was reported to accurately assess changes in hair density and diameter, suggesting its usefulness in monitoring alopecia progression and treatment response.