176 citations
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August 2015 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This study identified a distinct cytokine activation signature in alopecia areata, involving TH2, TH1, IL-23, and IL-9/TH9 pathways, suggesting potential targeting strategies similar to those in psoriasis and atopic dermatitis.
161 citations
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March 1992 in “International Journal of Dermatology” This study analyzed survey responses from 800 alopecia areata patients and found a possible genetic association with increased insulin-dependent diabetes mellitus in relatives but not in the patients themselves.
142 citations
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March 2019 in “Molecules/Molecules online/Molecules annual” This review discusses the role of the endocannabinoid system in skin health and disease, highlighting its potential for future research and applications, but reports no new experimental results.
141 citations
,
March 2011 in “Journal of Dermatology” This study in Japan found varying prevalence of skin disorders, with atopic dermatitis common in children and tinea pedis in the elderly, and observed gender differences in disease susceptibility.
136 citations
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May 2016 in “Phytotherapy Research” This systematic review suggests that turmeric and curcumin products, both oral and topical, may offer therapeutic benefits for various skin conditions, though further research is necessary to evaluate efficacy more thoroughly.
131 citations
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November 2010 in “Journal of the American Academy of Dermatology” This article reviews cyclosporine's mechanism, uses, and dosing in dermatology, but reports no new clinical findings, focusing instead on helping dermatologists integrate it safely into their practice.
128 citations
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September 2011 in “British Journal of Dermatology” Obesity is linked to various skin problems and may increase the risk of skin cancer.
124 citations
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October 2019 in “Frontiers in Immunology” This review discusses the role of the JAK-STAT pathway in autoimmune skin diseases and suggests potential therapeutic benefits of JAK inhibitors, but reports no new experimental results.
124 citations
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January 1995 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This article reports a case of Netherton's syndrome that responded to 12% ammonium lactate lotion, suggesting potential treatment benefits for skin and allergic symptoms in this rare condition.
114 citations
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October 2017 in “American journal of clinical dermatology” Adequate vitamin D is crucial for skin health and should be considered in dermatology.
100 citations
,
August 2022 in “Microbial Cell Factories” This review discusses the interactions between skin microbiota and human skin health, examining how imbalances may contribute to skin diseases, and reports no new clinical results.
100 citations
,
July 2018 in “Journal of The American Academy of Dermatology” This study found that alopecia areata is linked with a higher prevalence of systemic and psychiatric diseases, suggesting that physicians should monitor for these potential comorbidities.
95 citations
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July 2016 in “Journal of The American Academy of Dermatology” This review concluded that patients with alopecia areata consistently show poor health-related quality of life scores, similar to those in other chronic skin diseases like atopic dermatitis and psoriasis.
89 citations
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May 1999 in “Allergy” This article reviews the role of Pityrosporum (Malassezia) in skin conditions such as pityriasis versicolor, seborrheic dermatitis, and atopic dermatitis, and discusses treatment approaches; it reports no new clinical results.
88 citations
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May 2020 in “Clinical therapeutics” This review discusses the role of stress mediators in skin diseases and reports no new clinical results; the authors suggest further research in skin psychoneuroimmunology.
88 citations
,
April 2012 in “Journal of Investigative Dermatology” This study suggests that TRPV3 may play a key role in dry skin-related itch, indicating potential for TRPV3 antagonists in treating pruritus resistant to histamine H1R antagonists.
88 citations
,
January 2011 in “Annals of Dermatology” This review discusses the reclassification of pregnancy-related skin diseases and provides a management algorithm but reports no new clinical findings.
87 citations
,
February 2009 in “PubMed” This review discusses the potential causes and treatments for alopecia in nonhuman primates, emphasizing the need for comprehensive testing before attributing hair loss to stress.
84 citations
,
February 2015 in “Experimental Dermatology” This review discusses the role of PPARs in skin health, suggesting both potential benefits and adverse effects, but reports no new experimental results; the authors emphasize the need for more research to understand these pathways.
84 citations
,
March 2004 in “Veterinary Dermatology” In randomized controlled trials, this research reports that cyclosporin is as effective as glucocorticoids for treating canine atopic dermatitis and has potential benefits for other immune-mediated skin conditions in dogs.
78 citations
,
May 2019 in “Frontiers in Cellular and Infection Microbiology” This study found that the antimicrobial peptide DPK-060 effectively reduced bacterial counts of Staphylococcus aureus and was safe for topical use in preclinical models, although nanocarrier encapsulation did not enhance its efficacy.
77 citations
,
July 2020 in “Journal of the European Academy of Dermatology and Venereology” This review examines the skin exposome, including solar exposure, air pollution, hormones, nutrition, and psychological factors, but reports no new clinical results.
75 citations
,
August 2018 in “Biochemical pharmacology” This review discusses the potential of targeting the endocannabinoid system for treating skin disorders and reports no new clinical results, highlighting the need for further research.
73 citations
,
August 2019 in “Cell Proliferation” This review explores the interactions between the skin, peripheral nervous system, and immune system and reports no new results; the authors highlight the importance of understanding these connections for various skin conditions.
72 citations
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March 2023 in “Biomolecules” This study reviewed the use of dupilumab, beyond its approved indications for atopic dermatitis and prurigo nodularis, and found effective treatment reports for various chronic inflammatory skin diseases such as bullous autoimmune diseases, eczema, and alopecia areata, highlighting its broad potential in dermatology.
72 citations
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June 2019 in “International Journal of Cosmetic Science” This review discusses the biological properties of 18β‐glycyrrhetinic acid derived from licorice root, highlighting its potential anti-inflammatory, antioxidant, and antimicrobial benefits in treating dermatological disorders, and reports no new experimental results.
64 citations
,
January 2004 in “American journal of clinical dermatology” This review describes various types of folliculitis based on their causes, clinical manifestations, and treatments, but reports no new clinical results.
64 citations
,
December 1990 in “Journal of the American Academy of Dermatology” This review discusses the use of cyclosporine in dermatological conditions and its associated monitoring needs and potential side effects, but reports no new research results.
63 citations
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April 2018 in “Journal of the American Academy of Dermatology” This review discusses the efficacy and safety of topical JAK inhibitors for inflammatory skin conditions, reporting modest benefits in psoriasis and atopic dermatitis but mixed results for vitiligo and inconclusive data for alopecia areata.
62 citations
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June 2023 in “Acta Dermato Venereologica” This observational study found that patients with various skin diseases across 17 European countries experience higher levels of perceived stigmatization than skin-healthy controls, particularly those with psoriasis, atopic dermatitis, alopecia, and bullous disorders, with factors such as disease severity and psychological distress influencing stigmatization levels.