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      A Matter of Life and Death: Self-Renewal in Stem Cells

      research A matter of life and death: selfrenewal in stem cells

      150 citations , December 2012 in “EMBO Reports”
      This review explores the mechanisms of adult stem cell self-renewal, using skin as a model, and reports no new results but raises important unanswered questions in the field.

      research Population and Individual Stem Cell Dynamics in the Olfactory Epithelium

      January 2016 in “eScholarship (California Digital Library)”
      This dissertation reports that horizontal basal cells in the olfactory epithelium undergo symmetric divisions balanced by population asymmetry, which supports their renewal and differentiation during tissue homeostasis and regeneration.
      Runx Family Genes in Tissue Stem Cell Dynamics

      research Runx Family Genes in Tissue Stem Cell Dynamics

      6 citations , January 2017 in “Advances in Experimental Medicine and Biology”
      This review discusses the complex role of Runx family genes in regulating stem cells in blood and skin tissues and reports no new experimental results.
      Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate

      research Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate

      57 citations , March 2018 in “International Journal of Molecular Sciences”
      This review highlights recent advances in understanding how the extracellular matrix regulates epidermal stem cell fate, emphasizing the importance of the hair follicle stem cell niche, but reports no new empirical findings.
      Epidermal Keratinocyte Stem Cells: Their Maintenance and Regulation

      research Epidermal keratinocyte stem cells: their maintenance and regulation

      25 citations , December 1992 in “Seminars in cell biology”
      This review discusses how epidermal Langerhan's cells and dermal cells may influence keratinocyte environments, potentially aiding in the formation of stem cell niches and cellular variety in the basal layer, without providing novel results.
      Human Skin Stem Cells and the Aging Process

      research Human skin stem cells and the ageing process

      143 citations , September 2008 in “Experimental gerontology”
      This review discusses the diverse roles and characteristics of epidermal and dermal stem cells in skin regeneration and aging, highlighting their potential applications in regenerative medicine and reports no new clinical results.
      Cutaneous Epithelial Stem Cells

      research Cutaneous Epithelial Stem Cells

      November 2013 in “Elsevier eBooks”
      This review discusses the evolving understanding of epithelial stem cells, noting how new models challenge old assumptions and suggesting multiple stem cell populations contribute differently to skin and hair follicle regeneration.
      Clonal Analysis of Stem Cells in Differentiation and Disease

      research Clonal analysis of stem cells in differentiation and disease

      11 citations , July 2016 in “Current Opinion in Cell Biology”
      This review discusses stem cell behavior, highlighting their plasticity in tissue repair and the impact of somatic mutations on clonal expansion in early cancer, but reports no new experimental results.
      Normal Stem Cells and Cancer Stem Cells: Similar and Different

      research Normal stem cells and cancer stem cells: similar and different

      126 citations , April 2010 in “Seminars in Cancer Biology”
      This review discusses the similarities and differences between normal stem cell proliferation and cancer cell oncogenesis and concludes that understanding these mechanisms could improve cancer treatment strategies, but it reports no novel findings.
      Transcriptional Control of Epidermal Stem Cells

      research Transcriptional Control of Epidermal Stem Cells

      4 citations , January 2013 in “Advances in Experimental Medicine and Biology”
      This article reviews mammalian skin epidermis as a model for studying stem cell regulation, noting the utility of in vitro and ex vivo platforms, but it reports no new empirical findings.
      Long-Term Renewal of Hair Follicles from Clonogenic Multipotent Stem Cells

      research Long-term renewal of hair follicles from clonogenic multipotent stem cells

      291 citations , October 2005 in “Proceedings of the National Academy of Sciences of the United States of America”
      This study found that rat whisker follicle stem cells can be expanded in culture and transplanted to form functional hair follicles, demonstrating their multipotency and potential for regenerative medicine.
      Stem Cells Behind the Barrier: Mechanisms Regulating Epidermal Stem and Progenitor Cell Differentiation

      research Stem Cells behind the Barrier

      22 citations , June 2013 in “International journal of molecular sciences”
      This review discusses the mechanisms governing epidermal stem and progenitor cell differentiation, emphasizing the balance necessary for maintaining skin barrier function, and reports no new experimental findings.

      research Ontogeny of Skin Stem Cells and Molecular Underpinnings

      7 citations , July 2024 in “Current Issues in Molecular Biology”
      This review examines the complex mechanisms that regulate skin stem cell development, activation, and differentiation, emphasizing the molecular signaling pathways that influence their fate and contribute to skin homeostasis.
      TGF-β Family Signaling in Stem Cells

      research TGF-β family signaling in stem cells

      132 citations , August 2012 in “Biochimica et Biophysica Acta (BBA) - General Subjects”
      This review discusses the roles of TGF-β family signaling in regulating normal and cancer stem cells and highlights the need for further research to develop potential cancer treatments; it reports no new results.
      Stem Cell Niches in Mammals

      research Stem cell niches in mammals

      205 citations , August 2007 in “Experimental Cell Research”
      This review discusses advances in understanding mammalian stem cell niches, particularly in bone marrow, tooth, and hair follicle, and highlights the potential for developing therapies targeting these niches for tissue repair.

      research Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin

      2 citations , September 2023 in “International journal of molecular sciences”
      This review summarizes the roles of matricellular proteins in skin stem cell niches, highlighting their contribution to stem cell fate, self-renewal, and potential implications for wound healing and aging.

      research The stem cell niche

      209 citations , October 2008 in “The Journal of Pathology”
      This review discusses the niches supporting adult stem cells in various organisms, including well-studied germline niches and the less understood mammalian niches, but it reports no new research findings.

      research Epidermal stem cells: skin surveillance and clinical perspective

      19 citations , August 2024 in “Journal of Translational Medicine”
      This review explores recent advancements in understanding how various physiological and psychological factors, such as stress and aging, influence epidermal stem cell populations, highlighting their importance in immune-related skin disorders and potential for clinical applications.
      More Than One Way to Skin

      research More than one way to skin . . .

      218 citations , April 2008 in “Genes & Development”
      This research discusses how epithelial stem cells in the skin maintain normal homeostasis, contribute to wound repair, and highlights the importance of these processes, as defects can lead to skin diseases including cancers, but provides no new experimental results.