The Stem Cell Niche
October 2008
in “
The Journal of Pathology
”
TLDR Stem cell niches are essential for tissue health and repair.
The document discussed the concept of the stem cell niche, which was crucial for maintaining tissue homeostasis and responding to injury in adult organisms. It highlighted that the niche comprised both cellular and non-cellular components that regulated stem cells through physical contact and diffusible factors. The study examined well-understood niches in organisms like Caenorhabditis elegans and Drosophila melanogaster, and also explored the more complex niches in mammals, such as those supporting neural, epidermal, haematopoietic, and intestinal stem cells.
