The Stem Cell Niche

    October 2008 in “ The Journal of Pathology ”
    MR Walker, KK Patel, TS Stappenbeck
    TLDR Stem cell niches are essential for tissue health and repair.
    The document reviewed the concept of the stem cell niche, emphasizing its critical role in regulating stem cells and their progenitors across various systems, including the skin, hair follicles, and neural environments. It described the niche as a microenvironment providing essential support and regulatory signals, influencing stem cell self-renewal and differentiation. The review highlighted specific signaling pathways, such as Wnt, JAK-STAT, BMP, and Notch, and the importance of niche components like integrins and growth factors (EGF, FGF-2) in maintaining tissue homeostasis and responding to injury. The complexity of mammalian niches, particularly in neural and epidermal systems, was noted, with proteins like Aspm and Numb playing crucial roles. The document concluded that further research was needed to fully understand these interactions and develop therapeutic targets for tissue-specific diseases.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 523 results

      community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

      in Research/Science  92 upvotes 3 years ago
      The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

      community Hair theory Scar tissue and Verteporfin

      in Chat  25 upvotes 1 year ago
      A user suggests that deeper microneedling with Verteporfin injections might help regrow hair in areas with scar tissue, alongside a DHT blocker. Another user explains that hair loss might be due to reduced Wnt/β-Catenin signaling and suggests that treatments like Minoxidil, Finasteride, and microneedling could potentially reverse it.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  138 upvotes 1 year ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community New Treatments, and a Huge Group Buy with Lots of Research

      in Research/Science  109 upvotes 2 years ago
      A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

    Similar Research

    6 / 1000+ results