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Palliative chemotherapy is cost-effective for advanced gastric and colorectal cancer but not clearly for pancreatic-biliary cancer.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Pregnancy can cause skin darkening, varicose veins, more sweating, hair growth, hair loss after birth, nail changes, and gum inflammation.

Minoxidil promotes hair growth in male pattern baldness.

In Italian patients with lupus, the most common skin issue was chronic cutaneous lupus, especially discoid lesions, and nonspecific skin problems occurred in about a third of those with systemic lupus, mainly during active disease.

Hibiscus rosa-sinensis leaf extract helps hair grow longer and faster.

Choosing the right patients, using proper techniques, and having thorough knowledge are key to preventing and managing dermal filler complications.

Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

Potassium channel openers could help treat cardiovascular diseases and asthma but require better targeting to specific tissues for effective use.

Recombinant cytokine therapy can cause skin reactions ranging from mild to severe.

DHT may increase the risk of heart disease and death in elderly men.

Testosterone replacement may help some postmenopausal women with symptoms like fatigue and low libido, but more research is needed to fully understand its effects.

Pregnancy can cause skin pigmentation, stretch marks, and changes in hair, nails, and sweat glands, with most resolving after birth.

Minoxidil effectively treats severe hypertension but may cause side effects, so careful monitoring is needed.

Diazoxide, minoxidil sulphate, and cromakalim relax rat blood vessels by opening K+ channels, with some differences in their actions.

Skin problems in COVID-19 patients are rare and may be due to the body's complex immune response or blood clotting issues.

Etoposide is effective in treating several cancers, especially small cell lung cancer, with acceptable side effects.

Amenorrhea is relatively rare and initial testing should check FSH, TSH, and prolactin levels.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Myo-inositol may be more effective than metformin for inducing ovulation in women with PCOS.

The patient's liver did not fully grow back and she had serious temporary side effects after a very large liver surgery.

Lifestyle changes improve metabolism and fertility in overweight PCOS patients; anti-obesity drugs show potential but need more research.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

People with diabetes or obesity should manage their conditions carefully as they have a higher risk of severe COVID-19.

Kennedy's disease leads to muscle weakness and sensory issues, has no cure but manageable symptoms, and future treatments look promising.

The review recommends hormone replacement therapy for women with premature ovarian insufficiency to manage symptoms and protect health, with specific approaches for different groups.

Metabolic syndrome and PCOS are related but separate conditions, with metabolic syndrome increasing the risk of heart disease and diabetes.

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.