March 2025 in “Wound Repair and Regeneration” In a study using mouse models, researchers developed a gelatin methacryloyl scaffold with calcium-doped silica nanoparticles loaded with deferoxamine, which significantly improved skin flap survival and hair follicle growth, suggesting potential clinical applications in tissue regeneration.
5 citations
,
June 2023 in “BMC genomics” This study found that a specific genetic mutation in the Fgf5 gene may contribute to the long-hair trait in Angora rabbits by reducing the binding capacity of the FGF5 protein.
2 citations
,
February 2012 in “PubMed” This study found that Gp₄G increased hair length, papilla cell numbers, and versican deposition in treated animals, potentially through alterations in hair follicle phases and nucleotide concentrations.
7 citations
,
April 2020 in “JIMD Reports” In this follow-up of three siblings with ATP6AP1 deficiency, the researchers observed progression to total hearing loss, hair loss, and proteinuria.
20 citations
,
July 2005 in “Experimental dermatology” This study found that the fuzzy mutation in mice is linked to both structural hair defects and accelerated hair follicle cycling, influencing the regulation of hair cycle phases such as catagen and anagen.
11 citations
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October 2002 in “Genetics” This study mapped a spontaneous mouse hair mutation, "hague," to keratin genes on chromosome 15 but found no gene mutations in hague mice.
252 citations
,
March 1998 in “Developmental dynamics” This study suggests that fibroblast growth factors FGF-4, FGF-8, and FGF-9 may play redundant roles as signals in epithelial-mesenchymal interactions during multiple stages of tooth development in mice.
November 2005 in “CRC Press eBooks” This article reviews the development and challenges of skin penetration enhancers, highlighting their limitations in compatibility and safety, and reports no new clinical findings.
30 citations
,
October 2010 in “Biochemical and biophysical research communications” This study found that the Gsdma3 gene is necessary for normal hair follicle differentiation in mice, with its mutation leading to progressive hair loss and defects in hair structure.
In this study, researchers observed that during zebrafish fin regeneration, osteoblast Erk activity, influenced by Fgf receptor signaling, forms gradients scaling with amputation length, which predicts regenerative tissue growth and skeletal structure size.
June 2026 in “Journal of Cosmetic Dermatology” This study reported that microneedle-assisted delivery of PEGylated recombinant human fusion collagen significantly improved hair regrowth and density in an androgenetic alopecia mouse model and in a small clinical trial with AGA patients, suggesting potential efficacy and safety for this treatment approach.
9 citations
,
January 2014 in “Molecular Genetics and Metabolism Reports” This study discovered that a specific G to C mutation in the ornithine aminotransferase gene is linked to the retarded hair growth phenotype in mice and may serve as a model for human gyrate atrophy.
December 1987 in “Pediatric Dermatology” This article describes a previously unreported hair anomaly associated with facio-genito-popliteal syndrome and does not present new clinical results.
4 citations
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January 2023 in “Journal of Clinical Investigation” This study identified a recurrent mutation in the endothelin receptor type A associated with mandibulofacial dysostosis with alopecia, and proposed a mechanism involving increased ligand affinity due to structural changes.
This chapter reviews current and future strategies for identifying ligands and functions of orphan G protein-coupled receptors, but it reports no new experimental results.
February 2025 in “Advanced Composites and Hybrid Materials” This study reported that in animal studies of androgenetic alopecia, a biodegradable microneedle patch releasing glutamic acid promoted hair regeneration more effectively than daily minoxidil, with higher hair follicle counts and less frequent dosing, showing the potential for clinical application.
January 2020 in “프로그램북(구 초록집)” This study found that treating androgenetic alopecia patients with microneedle-delivered GFC containing FGF5s and NMN increased hair density and diameter compared to normal saline.
10 citations
,
November 2015 in “Experimental Dermatology” The study observed that mRAGE expression is prevalent in keratinocytes of the healthy human epidermis and may regulate inflammation and apoptosis to maintain skin homeostasis rather than responding to aging processes.
19 citations
,
January 2019 in “Animals” This study suggests that PDGFA and BMP2 play a role in the hair follicle cycle in cashmere goats, with PDGFA particularly involved in activating the growth phase.
10 citations
,
June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified FP-1 as a highly specific extracellular matrix protein in follicular papilla cells, which may play a role in hair growth regulation during specific hair cycle phases.
7 citations
,
March 2023 in “Lasers in Surgery and Medicine” This study found that a single ablative fractional laser treatment significantly reduced hedgehog pathway gene expression in microscopic murine basal cell carcinomas, nearly matching the effects of repeated topical vismodegib applications.
February 2026 in “The Plant Journal” This study found that in Arabidopsis, root hair-specific proteins ADF8 and ADF11 are crucial for responding to hormonal signals like auxin and ethylene, which in turn modulate actin filament dynamics and are key for root hair growth under various environmental conditions.
October 2024 in “SPIRE - Sciences Po Institutional REpository” This study highlights that human hair follicle dermal papilla cells and glypicans play crucial roles in regulating hair follicle stem cell differentiation.
5 citations
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March 2019 in “Journal of lipid research” This study reports new fluorogenic ceramidase substrates and highlights RBM14C24:1 as an efficient substrate for neutral ceramidase, while RBM15C18:1 is the best probe for measuring ACER1 and ACER2 activities, potentially aiding high-throughput screening for ceramidase inhibitors.
October 2022 in “ACS Applied Materials & Interfaces” This study reports that the newly developed SA-Ca(II) hydrogel has tunable mechanical properties, high biocompatibility, and potential applications in wearable protections and stimuli-responsive electronics.
80 citations
,
April 2011 in “Plant physiology” This study suggests that the GPX-PDE1 and GPX-PDE2 genes in white lupin enhance root hair development and contribute to Pi limitation acclimation by facilitating glycerophosphodiester degradation.
May 2026 in “Journal of Medicinal Chemistry” In this study, the authors developed a novel PROTAC named dAR-6–1, which demonstrated superior hair regeneration in an AGA mouse model compared to minoxidil, highlighting its promise as a therapy due to potent AR degradation and excellent skin permeability.
103 citations
,
June 2018 in “International Journal of Molecular Sciences” This review discusses the applications and research on fibroblast growth factors, including their use in wound healing, diabetes, and cancer, but it reports no new clinical results.
3 citations
,
December 2024 in “Journal of Animal Physiology and Animal Nutrition” In this study, researchers found that reducing FGF20 expression in dermal papilla cells of fine-wool sheep impedes the growth and differentiation of hair follicle stem cells, providing insights into wool trait improvement and regenerative medicine applications.
2 citations
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January 2014 in “Photochemical & photobiological sciences” This study suggests that the Grasp protein may play a role in regulating skin homeostasis following UVB exposure by influencing p53-mediated apoptotic responses in mice.