Epidermal Expression of Receptor for Advanced Glycation End Products (RAGE) Is Related to Inflammation and Apoptosis in Human Skin
November 2015
in “
Experimental Dermatology
”
Studysummary The study observed that mRAGE expression is prevalent in keratinocytes of the healthy human epidermis and may regulate inflammation and apoptosis to maintain skin homeostasis rather than responding to aging processes.
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The study, which analyzed skin samples from 67 patients, found that the expression of the receptor for advanced glycation end products (RAGE) in the human epidermis is significantly correlated with epidermal thickness and is predominantly expressed in keratinocytes, fibroblasts, and endothelial cells. The expression of the AGER gene, responsible for encoding membrane-bound RAGE (mRAGE), was positively associated with levels of pro-inflammatory cytokines and pro-apoptotic factors, indicating its potential role in regulating inflammation and apoptosis in the skin. The findings suggest that mRAGE may be important for maintaining skin homeostasis by monitoring and responding to acute epidermal reactions.
