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research Epidermal expression of receptor for advanced glycation end products (RAGE) is related to inflammation and apoptosis in human skin

10 citations , November 2015 in “Experimental Dermatology”

The study observed that mRAGE expression is prevalent in keratinocytes of the healthy human epidermis and may regulate inflammation and apoptosis to maintain skin homeostasis rather than responding to aging processes.

research The therapeutic promise of apoptosis

9 citations , March 2019 in “Science”

Blocking cell death in certain stem cells can improve wound healing and tissue regeneration.

research Apoptotic Cells May Drive Cell Death in Hair Follicles During their Regression Cycle

November 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study in live mice suggests that hair follicle regression involves apoptosis propagation towards stem cells, potentially slowed by a protective signal from the stem cells themselves.

research Interest of Panax Ginseng and Albizia Julibrissin extracts to prevent age-related hair density reduction

August 2019 in “Journal of the American Academy of Dermatology”

Ginseng and Albizia extracts help prevent hair thinning with age.

research 1366 Interest of Panax Ginseng and Albizia Julibrissin extracts to prevent age-related hair density reduction

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study observed that Ginseng and Albizia extracts, when used together, protected human dermal papilla cells from oxidative stress-induced senescence, and inhibited genes that suppress hair growth, indicating their potential in preventing age-related hair density reduction.

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community Brief summary of new dutasteride study linked to infertility and the limitations/problems with the study

in Finasteride/Dutasteride 34 upvotes 1 year ago

Dutasteride treatment may decrease sperm concentration, but levels remain above WHO recommendations and recover after discontinuation. The study has limitations, including small sample size and lack of pre-treatment sperm data, and does not assess other fertility factors.

community Someone please offer reassurance

in Minoxidil 3 upvotes 1 month ago

A 19-year-old male is experiencing hair shedding while using oral minoxidil, ketoconazole, dermastamping, and saw palmetto, and is considering switching to finasteride for better results. Users suggest that saw palmetto may not be effective and recommend finasteride instead, while also discussing other treatments like rosemary oil, peppermint oil, and pumpkin seed oil.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 2 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

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