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The study observed that mRAGE expression is prevalent in keratinocytes of the healthy human epidermis and may regulate inflammation and apoptosis to maintain skin homeostasis rather than responding to aging processes.

Blocking cell death in certain stem cells can improve wound healing and tissue regeneration.

This study in live mice suggests that hair follicle regression involves apoptosis propagation towards stem cells, potentially slowed by a protective signal from the stem cells themselves.

Ginseng and Albizia extracts help prevent hair thinning with age.

This study observed that Ginseng and Albizia extracts, when used together, protected human dermal papilla cells from oxidative stress-induced senescence, and inhibited genes that suppress hair growth, indicating their potential in preventing age-related hair density reduction.

This study found that a 3D wound model, the 3DWoundSE, showed improved responsiveness to injury and cytotoxic stimuli compared to an intact 3D skin equivalent, offering a reproducible and ethical alternative to animal models for early wound response assessment in dermatological research and drug development.

This study found that hair follicle stem cell-derived secretome mitigated cell death, apoptosis, and inflammation while upregulating neurotrophic factors in astrocytes exposed to oxygen-glucose deprivation, an in vitro ischemic stroke model, suggesting potential therapeutic benefits in stroke recovery.

This study reported that depleting the pro-apoptotic protein Bax in hair follicle stem cells enables these cells to kill nearby viable cells by sequestering TNFα, which increases the stem cell pool and accelerates tissue regeneration, suggesting potential implications for therapies targeting tissue repair and cancer.

In this study using live mice, researchers observed that during hair follicle regression, apoptosis in basal cells may propagate by triggering neighboring cells, potentially regulated by a gradient of pro-survival signals from stem cells, and proposed a testable mechanism to further explore this process.

This study suggests that human placenta treatment may promote hair regrowth in chemotherapy-induced alopecia by inhibiting apoptosis and encouraging hair follicle proliferation in a mouse model.

In this study, researchers observed that patients with androgenetic alopecia show differences in scalp microbial communities compared to the general population, including an increase in Cutibacterium acnes, particularly in males, which may interact with lipid and immune pathways to contribute to hair follicle miniaturization.

This study found that Acanthus ebracteatus extract and verbascoside induced dermal papilla cell proliferation and reduced inflammatory cytokine release in vitro, suggesting potential for anti-hair loss applications.

This study reported that in laboratory conditions, a cell-free supernatant of Bifidobacterium longum BB536 promoted human dermal papilla cell proliferation and reduced damage and apoptosis caused by dihydrotestosterone, suggesting potential use as a preventative treatment for androgenic alopecia by modulating specific signaling pathways.

In this study, the combination of low level light therapy with arginine, arterial extract, or biotin tripeptide-1 was associated with improvements in hair density and follicle structure in androgenic alopecia.

In this study, short-term finasteride treatment reduced apoptotic factors caspase-7 and IGFBP-3 in prostate cancer cells but did not significantly affect androgen receptor expression compared to placebo.

This study found that ginsenoside F2 may suppress hair cell apoptosis and improve hair growth outcomes in a DHT-induced hair loss model more effectively than finasteride.

This study found that cyclosporine A's enhancement of hair growth in mice is partly due to its ability to block the nuclear translocation of apoptosis-inducing factor, slowing the hair follicle transition to the catagen phase.

This study found that vascular endothelial growth factor may protect hair follicle stem cells from androgen-induced apoptosis in androgenic alopecia patients via the PI3K/Akt pathway.

In this study, researchers found that p75 neurotrophin receptor signaling affects apoptosis during hair follicle regression in mice, and altering its activity might help manage disorders involving early catagen entry.

This study suggests that geranyl acetate may offer protective, anti-inflammatory, and cytoprotective effects against PPD-induced toxicity in keratinocyte cells, indicating its potential as a plant-derived treatment.

This study demonstrated that SHFKO significantly accelerated healing in acute radiation-induced skin injuries, with mechanisms involving apoptosis inhibition, suppression of inflammation, and restoration of ROS balance, suggesting its potential as a novel multi-target therapy for radiodermatitis.

This study suggests that nerve growth factor plays a crucial role in the stress-induced termination of hair growth in mice, and its antagonism might offer a therapeutic approach to mitigate stress-related hair loss.

This study found that the small molecule honokiol may protect against inflammation, collagen breakdown, and cell damage caused by cigarette smoke in skin cells cultured in vitro.

This study found that the retinoid all-trans retinoic acid induced a catagen-like stage in human scalp hair follicles, suggesting upregulation of TGF-beta2 as a contributing mechanism.

This study found that prolactin can induce premature catagen in both mouse and human hair follicles and suggests that targeting prolactin and TGF-β receptors may be promising for treating androgenetic alopecia.

This article discusses how nutritional and environmental factors, along with antioxidant supplementation, may improve hair growth by mitigating the effects of androgens and reports no new clinical results.

This review suggests that isotretinoin's effects on severe acne and various cancers may result from apoptosis, which might also explain its adverse effects through genetic variability.

This review assessed experimental studies on herbs used for alopecia, identifying potential mechanisms involving hair cycle management and keratinocyte processes, but highlighted a need for improved evidence on quality control and toxicity of these herbal treatments.

This study found that human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) significantly prevented hair loss induced by dexamethasone in a mouse model and enhanced cell proliferation in human hair follicle cells, suggesting a protective effect against stress-related hair loss.

This study found that VEGFR-2 activation may play a role in hair follicle differentiation, proliferation, and apoptosis by co-expressing with several key proteins in normal human scalp skin.