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      Alopecia Areata: A Review of Disease Pathogenesis

      research Alopecia areata: a review of disease pathogenesis

      191 citations , May 2018 in “British journal of dermatology/British journal of dermatology, Supplement”
      This study reviewed recent theories on alopecia areata's pathogenesis, highlighting its autoimmune nature due to immune privilege disruption in hair follicles, and noted current treatments have limited efficacy with high relapse rates, underscoring the need for further research into its mechanisms for better therapies.
      Alopecia Areata: Treatment Options and Efficacy

      research Alopecia areata

      182 citations , December 2017 in “Journal of the American Academy of Dermatology”
      This article reviews current and emerging treatments for alopecia areata, including Janus kinase inhibitors, highlighting variability in clinical outcomes and the lack of sustained remission.
      Guidelines for the Management of Alopecia Areata

      research Guidelines for the management of alopecia areata

      182 citations , October 2003 in “British Journal of Dermatology”
      These guidelines for alopecia areata management, prepared by the British Association of Dermatologists, provide evidence-based treatment recommendations and insights into the condition's epidemiology, diagnosis, and investigation.

      research Alopecia Areata in Aging C3H/HeJ Mice

      178 citations , June 1994 in “Journal of Investigative Dermatology”
      This study found that a non-scarring alopecia in C3H/HeJ mice resembles human alopecia areata and may serve as a valuable model for studying specific subtypes of the human condition.
      Alopecia Areata Profiling Shows TH1, TH2, and IL-23 Cytokine Activation Without Parallel TH17/TH22 Skewing

      research Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing

      176 citations , August 2015 in “ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology”
      This study identified a distinct cytokine activation signature in alopecia areata, involving TH2, TH1, IL-23, and IL-9/TH9 pathways, suggesting potential targeting strategies similar to those in psoriasis and atopic dermatitis.
      Interventions for Alopecia Areata

      research Interventions for alopecia areata

      164 citations , April 2008 in “Cochrane library”
      This review of interventions for alopecia areata found no significant treatment benefits for hair growth compared to placebo, indicating a need for larger, well-conducted studies.

      research The autoimmune basis of alopecia areata: A comprehensive review

      162 citations , October 2014 in “Autoimmunity reviews”
      This review discusses alopecia areata, highlighting its autoimmune aspects, environmental triggers, and current treatment options, but reports no new clinical results; recent studies suggest JAK pathway intervention may offer therapeutic potential.

      research PROFILE OF ALOPECIA AREATA: A QUESTIONNAIRE ANALYSIS OF PATIENT AND FAMILY

      161 citations , March 1992 in “International Journal of Dermatology”
      This study analyzed survey responses from 800 alopecia areata patients and found a possible genetic association with increased insulin-dependent diabetes mellitus in relatives but not in the patients themselves.
      Alopecia Areata: Overview and Treatment Options

      research Alopecia areata

      151 citations , February 2007 in “International Journal of Dermatology”
      This review explores the causes and mechanisms of alopecia areata and discusses current treatments, reporting no new clinical findings.
      The Role of Scalp Dermoscopy in the Diagnosis of Alopecia Areata Incognita

      research The role of scalp dermoscopy in the diagnosis of alopecia areata incognita

      150 citations , April 2008 in “Journal of The American Academy of Dermatology”
      This study found that videodermoscopy reveals distinct dermoscopic features in patients with alopecia areata incognita, aiding in biopsy decisions by identifying the appropriate sampling area and potentially avoiding unnecessary procedures.
      Two Phase 3 Trials of Baricitinib for Alopecia Areata

      research Two Phase 3 Trials of Baricitinib for Alopecia Areata

      148 citations , March 2022 in “The New England Journal of Medicine”
      In two phase 3 trials, this study found that oral baricitinib significantly improved hair regrowth compared to placebo in adults with severe alopecia areata after 36 weeks, though longer trials are needed to ascertain its long-term efficacy and safety.
      Alopecia Areata: A Multifactorial Autoimmune Condition

      research Alopecia areata: A multifactorial autoimmune condition

      148 citations , December 2018 in “Journal of autoimmunity”
      This review discusses genetic and environmental factors contributing to autoimmunity in alopecia areata and reports no new clinical findings, emphasizing the need for further study on its aetiology and pathophysiology.
      Epidemiology and Burden of Alopecia Areata: A Systematic Review

      research Epidemiology and burden of alopecia areata: a systematic review

      144 citations , July 2015 in “Clinical, Cosmetic and Investigational Dermatology”
      This review reports that alopecia areata affects about 2% of people globally and is linked with psychiatric and medical comorbidities, highlighting its significant disease burden.

      research Autoimmunity: Alopecia Areata

      143 citations , January 2004 in “Journal of Investigative Dermatology Symposium Proceedings”
      This review discusses the autoimmune nature of alopecia areata, potential therapeutic targets, and highlights the need for further studies on immunomodulatory treatments and genetic factors, but it reports no new clinical results.

      research Placebo-controlled oral pulse prednisolone therapy in alopecia areata

      141 citations , February 2005 in “Journal of the American Academy of Dermatology”
      In this study, oral prednisolone pulse therapy led to significant hair regrowth in some patients with extensive alopecia areata, whereas no improvement was seen in the placebo group.
      Tofacitinib for the Treatment of Alopecia Areata and Variants in Adolescents

      research Tofacitinib for the treatment of alopecia areata and variants in adolescents

      139 citations , November 2016 in “Journal of the American Academy of Dermatology”
      In this retrospective review, tofacitinib treatment was associated with clinically significant hair regrowth in most adolescent patients with alopecia areata, though limitations suggest further studies are needed to confirm these findings.

      research Hair follicle immune privilege and its collapse in alopecia areata

      134 citations , July 2020 in “Experimental dermatology”
      This review discusses immune privilege in anagen hair follicles and its collapse in alopecia areata, emphasizing the importance of restoring this function for effective management and disease relapse prevention.

      research JAK inhibitors for alopecia areata: a systematic review and meta‐analysis

      130 citations , February 2019 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”
      This study found that JAK inhibitors for alopecia areata showed promising response rates, with 72.4% of 289 cases responding, and oral administration achieving better outcomes than topical treatment, but recurrence occurred when treatment stopped. Further large-scale studies are needed to confirm these findings.
      Alopecia Areata: Pathogenesis And Treatment

      research Alopecia areata: Pathogenesis and treatment

      122 citations , November 1984 in “Journal of the American Academy of Dermatology”
      This review discusses the potential autoimmune pathogenesis and various contributing factors of alopecia areata, noting that current treatments remain palliative while emerging therapies offer new hope for extensive cases.