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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

Eating a high-glycemic diet may worsen acne by increasing certain protein levels and expressions in the skin.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Low-level laser therapy might help hair growth, but more research is needed.

Animal models have helped understand hair loss from alopecia areata and find new treatments.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

RTA 408 cream protects mice from radiation skin damage.

Human liver cells stick to hair protein materials mainly through the liver's asialoglycoprotein receptor.

miR-22, a type of microRNA, controls hair growth and its overproduction can cause hair loss, while its absence can speed up hair growth.

The document concludes that hair transplantation and gene therapy may be important for future hair loss treatment.

Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.

The drug enzalutamide may reduce the ability of the virus causing COVID-19 to enter lung cells.

Red Ginseng Extract may help human hair grow by activating growth pathways and blocking negative effects of certain hormones.

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

A 3-month stay in space causes skin thinning, disrupts hair growth, and changes muscle-related genes in mice.

Injecting a special gel with human protein particles can help hair grow.

Tumor suppressors help control inflammation in cancer and restoring their function could lead to new treatments.

Minoxidil boosts hair growth by triggering growth factor release from specific stem cells.

Damaging mitochondrial DNA in mice speeds up aging due to increased reactive oxygen species, not through the p53/p21 pathway.

Minoxidil and ATRA together boost hair growth more effectively than minoxidil alone.

Beard and scalp hair cells have different gene expressions, which may affect beard growth characteristics.

Group a wide range of chemicals, not just phthalates, for assessing risks to male reproductive health.

Low-Level Light Therapy (LLLT) is a safe and effective method for skin rejuvenation, acne treatment, wound healing, body contouring, and hair growth, but more well-designed trials are needed for confirmation.

Sex hormones affect brain injury differently in males and females.

Vitamin D3 can help improve hair growth by enhancing the function of specific skin cells and could be useful in hair regeneration treatments.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

The model suggests that scalp tension could lead to hair loss, with factors like blood vessel hardening, enlarged oil glands, and poor microcirculation also playing a role. It also hints at a possible link between skull shape and baldness pattern.