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Higher androgen levels and site-specific AR expression cause sex-related skeletal differences, and certain steroids can boost AR expression and androgen effects in bone cells.

Reduced AR gene methylation may cause early pubic hair growth in girls.

G allele of AR Stul polymorphism linked to higher hair loss risk, especially in white people.

AR gene not major factor in female hair loss; different from male hair loss.

The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

The new anti-acne treatment HA-P5 effectively reduces acne by targeting two key receptors and avoids an enzyme that can hinder treatment.

Male yak hair growth is influenced by DHT synthesis, which is promoted by 5α-red1 and AR during growth phases, while E2 may inhibit growth through ERα.

Higher levels of heat shock protein 27 and lower levels of miR-1 can increase AR levels, leading to hair loss in men.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

ERG increases SOX9, promoting prostate cancer growth and invasion.

Blocking testosterone speeds up wound healing in males.

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Researchers developed new compounds that target the androgen receptor effectively with fewer side effects.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.

A three-month treatment with a GnRH agonist significantly lowered androgen levels and 5α-reductase activity in men with benign prostatic hyperplasia.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.

Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.

The length of the CAG repeat in the androgen receptor gene affects the risk and progression of prostate cancer, BPH, infertility, and undermasculinized genitalia.

Androgen receptor activity blocks Wnt/β-catenin signaling, affecting hair growth and skin cell balance.

The conclusion is that androgen receptor gene polymorphism might be a marker for polycystic ovary syndrome, but more research is needed.

Longer CAG repeat lengths in the androgen receptor gene are linked to higher testosterone levels in women with PCOS.

Finasteride, a hair loss drug, may cause long-term sexual side effects due to changes in hormone receptor levels.

Androgen receptor signaling causes early aging of cells important for hair growth by damaging their DNA.

Human keratinocytes do not naturally respond to androgens.