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The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.

5α reductase inhibitors treat hair loss but may cause sexual side effects and risks.

Melatonin helps Cashmere goats grow more hair by affecting certain genes and cell pathways.

Cellular senescence has both cancer-blocking and cancer-promoting effects, and targeting senescent cells may improve health and lifespan.

Women with androgen excess, especially those with PCOS, have a much higher risk of heart disease and stroke.

The conclusion is that better understanding and more research are needed to effectively manage follicular and scarring disorders in skin of color, with an emphasis on patient education and cultural awareness.

Adult stem cells are important for tissue repair and have therapeutic potential, but more research is needed to fully use them.

Early onset baldness in men may indicate a condition similar to PCOS, linked to heart disease, diabetes, and prostate issues.

There is no significant link between male pattern baldness and insulin resistance.

Certain microRNAs are linked to various skin diseases and could be used to diagnose and treat these conditions.

Finasteride reduces corpus cavernosum weight but doesn't affect erectile response in rats.

New male hormonal contraceptives show promise but need more research on long-term effects and funding for larger trials.

Altered retinoid metabolism in cicatricial alopecia suggests a balanced vitamin A diet may prevent the condition.

Nellore cattle have genetic variations linked to their adaptation to tropical environments.

Obese and non-obese women with PCOS have higher heart risk markers, especially if they are obese.

Normal levels of DHT can reduce belly fat and increase muscle, but too much can lead to hair loss, prostate issues, and possibly heart disease.

The document suggests that certain protein deficiencies and scalp blistering in Epidermolysis Bullosa may cause hair loss.

Cross-sex hormone therapy is important for managing gender dysphoria and requires careful monitoring and healthcare provider education.

Thread-embedding therapy helped hair grow back in mice and might do the same in humans.

Mesenchymal stromal cells may help treat severe COVID-19, but more research is needed to confirm their effectiveness.

Some medications for bladder problems can cause memory issues or mood changes, and doctors should monitor these side effects.

Personalized treatment with inhibitors, minoxidil, and laser therapy helps hair loss.

Some skin problems can be signs of diabetes or other metabolic diseases and recognizing them can help diagnose and treat these diseases early.

Obesity is linked to various skin disorders, which can help with early diagnosis and prevention of long-term health issues.

Puberty often causes skin issues like acne and excessive sweating, and treatments require patience as results may vary.

People with alopecia areata have higher insulin resistance.

Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

The document concludes that diagnosing PCOS in teenagers is difficult and should focus on specific hormone levels and menstrual irregularities, while also considering treatment for symptoms and related health issues.

The document suggests that blocking sweat glands with antiperspirants might allow skin-generated hormones to be absorbed, possibly increasing breast and prostate cancer risk.