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The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

Male yak hair growth is influenced by DHT synthesis, which is promoted by 5α-red1 and AR during growth phases, while E2 may inhibit growth through ERα.

AI and AR are improving cosmetic dermatology but face challenges like data quality and ethical concerns.

Higher levels of heat shock protein 27 and lower levels of miR-1 can increase AR levels, leading to hair loss in men.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

ERG increases SOX9, promoting prostate cancer growth and invasion.

Blocking testosterone speeds up wound healing in males.

Essential oils from Curcuma species, like turmeric, have compounds that can fight inflammation, cancer, and bacteria, and can also stimulate hair regrowth in bald males.

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.

Androgens can help prevent memory problems caused by apoE4.

Researchers developed new compounds that target the androgen receptor effectively with fewer side effects.

Male pattern baldness involves hormones and cell signals affecting hair growth.

Androgens have complex effects on hair growth, promoting it in some areas but causing hair loss in others, and our understanding of this is still evolving.

Insufficient androgen action in male fetuses can cause genital development issues due to genetic mutations or environmental chemicals.

Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.

A three-month treatment with a GnRH agonist significantly lowered androgen levels and 5α-reductase activity in men with benign prostatic hyperplasia.

EDA2R gene linked to hair loss.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.

Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

The length of the CAG repeat in the androgen receptor gene affects the risk and progression of prostate cancer, BPH, infertility, and undermasculinized genitalia.

Oral retinoids are effective for severe skin conditions but require careful use due to side effects.

Mouse genital development depends on male or female hormones for specific features.

A gene called HDAC9 might be a new factor in male-pattern baldness.

Exemestane may protect bones by stimulating osteoblast growth through androgen-related pathways.