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Topical patidegib gel effectively treats basal cell carcinoma in Gorlin syndrome patients without causing the side effects seen with oral treatments.

Disrupted cholesterol production impairs hair follicle stem cells, leading to hair loss.

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.

Removing REDD1 in mice increases skin fat by making fat cells larger and more numerous.

Mackerel fermented fish oil protects skin cells from damage by UVB light.

Mutations in the P2RY5 gene cause hereditary woolly hair.

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

The paper concludes that understanding melanocyte development can help in insights into skin diseases and melanoma diversity.

Different types of fibroblasts play various roles in diseases and healing, and more research on them could improve treatments.

Alopecia areata is an autoimmune condition causing hair loss, influenced by genetics, stress, and diet, and may be prevented by a high soy oil diet.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.

The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

Stem cell niches are crucial for regulating stem cell renewal and differentiation, and understanding them can help in developing regenerative therapies.

Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.

Certain inhibitors slow down plant growth by causing early cell specialization without changing the cell development pattern.

Understanding different types of skin cells, especially fibroblasts, can lead to better treatments for wound healing and less scarring.

Cathepsin L is essential for normal hair growth and development.

Different types of stem cells and their environments are key to skin repair and maintenance.

Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.

Oxidative stress contributes to hair graying and loss as we age.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Dexamethasone speeds up hair loss in mice, while cyclosporin A slows it down.

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

Hair, teeth, and mammary glands develop similarly at first but use different genes later.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

Stress increases a factor in mice that leads to hair loss, and blocking this factor may prevent it.