31 citations
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May 2021 in “Journal of endocrinological investigation” This study in Italy found that APS-1, a rare disorder, is associated with various AIRE gene mutations and most individuals have autoantibodies such as IFNωAbs, which are markers of the condition.
May 2023 in “Sučasna pedìatrìâ. Ukraïna” In a clinical observation study, researchers documented a case of total alopecia in an 11-year-old child, highlighting a potential link to genetic conditions such as autoimmune polyendocrinopathy candidiasis-ectodermal dystrophy (APECED syndrome) requiring further genetic and serological testing to verify the diagnosis.
92 citations
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January 2012 in “International Journal of Biological Sciences” This article proposes an updated naming system for keratin-associated proteins and genes, aiming to improve data storage and retrieval by including species information and genetic variation.
January 2024 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers found that AP-2α and AP-2β are critical for maintaining epidermal homeostasis in adult skin, with their combined loss leading to severe skin and hair abnormalities and early skin inflammation due to impaired keratinocyte differentiation.
September 2012 in “The Thai journal of veterinary medicine” In this case study, apitoxin aquapuncture combined with herbal medicine was reported to have a favorable therapeutic effect in treating canine superficial pyoderma.
December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that AP-2α and AP-2β transcription factors are crucial for maintaining adult skin homeostasis, with their inactivation in keratinocytes leading to impaired differentiation, hair abnormalities, and inflammation, highlighting their key regulatory roles.
20 citations
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August 2003 in “Clinical and Experimental Dermatology” In this study, a novel E583V missense mutation in the hairless gene was identified in an Italian family with atrichia with papular lesions, reinforcing the significance of zinc-finger and LXXLL domains in this condition.
August 2018 in “Journal of the American Academy of Dermatology” This study reported that acupuncture combined with topical Aloe vera and celery gel reduced hair loss from alopecia androgenetica after 28 days of treatment.
September 2023 in “Journal of the American Academy of Dermatology” In this study of pediatric melanocytic lesions, researchers at Massachusetts General Hospital observed no concurrent BAP1 loss and BRAFV600E positivity, characteristics of adult BIMT, suggesting that these tumors may develop at a later age rather than in childhood.
2 citations
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March 2011 in “International Journal of Dermatology” This case report describes an 18-year-old male with IFAP syndrome, confirmed by total hair loss, severe photophobia, and characteristic skin changes, marking a rare presentation of the condition.
3 citations
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January 2013 in “Dermatology” This study identified novel compound heterozygous mutations in the hairless gene among a non-consanguineous Chinese family with congenital atrichia, illustrating phenotypic variations due to founder or modifier genes.
16 citations
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July 2007 in “Facial Plastic Surgery Clinics of North America” This article reviews approaches to facial aging in Asian patients, discussing cultural perspectives and proposing a new paradigm of youthful appearance, but provides no new clinical results.
June 2026 in “Pediatric Dermatology” This pilot study found that using the Breathr mindfulness app daily provided limited anxiety relief for some adolescents with alopecia areata over a three-month period.
3 citations
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January 2014 in “Indian dermatology online journal” This case report describes a 10-day-old female with aplasia cutis congenita, presenting with two spontaneously healing ulcers on her buttock and no associated abnormalities.
January 2014 in “China Animal Husbandry & Veterinary Medicine” In this study, researchers observed that the KAP8-1 gene influences skin and hair follicle development and wool quality with varying expression levels in different Ovis aries crossbred varieties.
This study found that inhibiting AP-1 activity in mice can induce lineage transdifferentiation between squamous and sebaceous tumors, suggesting AP-1's role in maintaining tumor cell identity.
10 citations
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August 2019 in “European Journal of Dermatology” This abstract provides no new clinical results; it discusses the role of surgery and interventional radiotherapy in treating cutaneous squamous cell carcinoma.
February 2024 in “Archiv EuroMedica” This review suggests that annurca apple extract, rich in polyphenols, may be a promising alternative for treating baldness, though further research is needed to clearly assess its effectiveness compared to existing treatments.
March 2023 in “Agroland: The Agricultural Sciences Journal/Agroland : The Agricultural Sciences Journal” This review discusses the potential cosmeceutical benefits of Pontianak Aloe Vera, highlighting its use in products for skin and hair care, and reports no new results.
2 citations
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August 2019 in “BMC Complementary and Alternative Medicine” This study found that ethanolic asiasari radix extract may induce apoptosis in G361 melanoma cells through ROS-dependent regulation of p53, suggesting potential as a medicinal option for melanoma.
August 2018 in “Archives on veterinary science and technology” This review discusses alopecia in nonhuman primates in research settings and reports no new findings, emphasizing documentation and therapeutic intervention importance during regulatory inspections.
November 2022 in “Journal of Investigative Dermatology” This study found that apocynin restored collagen production, reduced DNA damage and senescence, and protected skin stem cells from aging in UVB-exposed human keratinocytes.
January 2007 in “대한피부과학회지” In this clinical trial, the topical agent AP-FHG0604T significantly increased hair counts and growth rates in women with female pattern hair loss compared to a placebo, though some reported mild local irritation.
5 citations
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January 2016 in “Stem Cells International” This study found that epidermal stem cells in nonglabrous skin are connected to the distal end of the arrector pili muscle, which may play a role in epidermal renewal and wound healing.
8 citations
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January 2011 in “International journal of trichology” This report discusses the accurate diagnosis of atrichia with papular lesions, emphasizing its distinction from alopecia universalis to prevent unnecessary steroid treatment, and presents a case matching APL diagnostic criteria.
This study observed that the development of the pars intermedia in long-tailed macaques is closely associated with changes in skin pigmentation during pre- and postnatal periods through melanocyte-stimulating hormone and ACTH activity.
2 citations
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April 2025 in “Frontiers in Genetics” This study investigated the genetic basis of coat color variation in cattle using skin transcriptome and whole-genome analyses, identifying the ASIP gene as a significant determinant that is differentially expressed and under strong positive selection in black and brown cattle breeds.
1 citations
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July 2016 in “International Journal of Dermatology” This article discusses androgenetic alopecia in Amerindian Mapuche people from southern Chile and reports no new clinical findings.
11 citations
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February 2011 in “Current Zoology” The researchers reported that alopecia is common in Japanese macaques, particularly adult females, and varies seasonally and between different populations, with a new scoring system proposed for monitoring.