Hair Loss in Laboratory Bred Macaques: An Idiopathic Disorder of Major Consequence

The document reviewed the issue of idiopathic hair loss in laboratory-bred macaques, highlighting concerns raised by sponsors and regulatory authorities during site visits. It aimed to clarify the clinical findings of alopecia in these primates and reassure that hair loss does not necessarily indicate maltreatment or neglect. The review noted that self-directed behaviors leading to self-injury are common in both nonhuman primates and humans. It emphasized that the causes of alopecia in both free-range and laboratory-maintained monkeys, as well as in humans, involved multiple factors beyond the control of behavioral management or therapy. The document stressed the importance of thorough documentation of observations, progression, recurrence, and therapeutic interventions to prevent issues during regulatory inspections.