73 citations
,
November 2001 in “Journal of Investigative Dermatology Symposium Proceedings” This review examines histochemical and immunohistochemical markers to differentiate apocrine and eccrine sweat glands, highlighting their distinct markers, though it reports no new clinical findings.
84 citations
,
June 2010 in “The Plant Cell” In this study, disruptions in phospholipase A2 activity in Arabidopsis thaliana significantly impaired the plasma membrane localization of PIN proteins, affecting auxin transport and root development.
2 citations
,
January 1997 in “Journal of the society of cosmetic chemists” This study found that among 120 men, two antidandruff shampoos increased sebum excretion rate, while one shampoo decreased sebum output, highlighting distinct effects on the follicular reservoir.
1 citations
,
September 2017 in “Elsevier eBooks” Diuretics help the body get rid of excess salt and water by acting on the kidneys in different ways.
May 2026 in “Journal of Assisted Reproduction and Genetics” In this study, researchers developed and tested a novel peptide, AMHR2BP, which mimics the function of Anti-Müllerian hormone to protect ovarian follicles in mice, showing promise for preserving ovarian health during chemotherapy without causing toxicity.
19 citations
,
September 2013 in “Psychoneuroendocrinology” Blocking CYP17A1 enzyme may help improve certain brain function issues related to dopamine.
9 citations
,
July 2025 in “Pharmaceuticals” This review highlights the therapeutic potential of plant-derived exosomes, noting their larger size compared to animal-derived exosomes and usefulness in targeted drug delivery and inter-kingdom communication. It summarizes existing research on their biogenesis, characterization, and engineering for drug delivery, indicating significant opportunities for biotechnological advancements.
11 citations
,
February 2011 in “International Journal of Molecular Sciences” This article reviews sPLA2-mediated phospholipid metabolism using sPLA2 transgenic/knockout mice and lipid mass spectrometry, offering insights into the distinct roles of sPLA2 enzymes in various biological events.
91 citations
,
December 2019 in “The EMBO Journal” This study found that the E3 ligases NEDD4 and NEDD4L regulate intestinal stem cell priming by degrading the LGR5 receptor, and their loss leads to increased Wnt activation and crypt proliferation, which in turn accelerates intestinal tumor progression in mice.
26 citations
,
August 2018 in “Journal of Investigative Dermatology” This study found that TRPV3 activation in human sebocytes inhibits lipid synthesis and triggers proinflammatory cytokine expression, suggesting a role in the pathogenesis of dry skin-associated inflammatory dermatoses.
195 citations
,
February 2005 in “Journal of biological chemistry/The Journal of biological chemistry” This study shows that ZIP7 is a functional zinc transporter in mammalian cells, facilitating the movement of zinc from the Golgi apparatus to the cytoplasm.
18 citations
,
October 2019 in “Advanced Pharmaceutical Bulletin” This study found that finasteride microemulsions significantly increased skin permeability in vitro, highlighting the potential for enhanced delivery of this drug through the skin.
56 citations
,
November 2007 in “Molecular and cellular endocrinology” This study identified enzymes responsible for regulating androgen action in the human prostate, suggesting that inhibiting AKR1C2 or RL-HSD may have therapeutic potential in androgen insufficiency or benign prostatic hyperplasia, respectively.
April 2026 in “International Journal of Drug Delivery Technology” This study found that Lactobacillus acidophilus cell-free supernatant caused significant cytotoxicity, reduced migratory ability, and induced apoptosis in cervical cancer cell lines, suggesting its potential as a non-toxic adjunct therapy for cervical cancer.
14 citations
,
November 2024 in “Pharmaceuticals” This study found that using spanlastics, a nano, surfactant-based drug delivery system, improved the bioavailability, drug release characteristics, and pharmacokinetic behavior of famotidine, a poorly soluble drug, by enhancing its dissolution and membrane permeation.
71 citations
,
January 2019 in “International journal of biological sciences” This study proposes the miR-22-5p-LEF1 axis as a novel pathway that may regulate hair follicle stem cell proliferation.
April 2023 in “Journal of Investigative Dermatology” This study found that LSD1 is crucial for embryonic skin barrier formation in mice, revealing its significant role in epidermal development and suggesting its potential as a target in skin diseases with barrier defects.
16 citations
,
April 2021 in “Plant Signaling & Behavior” This study found that in Arabidopsis, the MYB30-EIN3 module plays a role in adapting root hair development to phosphate deficiency, potentially enhancing phosphate uptake from soil.
July 2026 in “Dermatological Reviews” This narrative review highlights the potential of exosomes as a promising platform for precision diagnostics, regenerative medicine, and targeted therapeutics in dermatology, while noting challenges such as standardization, manufacturing, and regulatory approval that must be resolved before widespread clinical use.
6 citations
,
April 2013 in “British Journal of Dermatology” This article reviews various histological features of hidradenitis suppurativa and proposes discrepancies with previous nomenclature, reporting no new clinical findings; the authors highlight the need for revised understanding.
3 citations
,
July 2018 in “Biomedicine & pharmacotherapy” This study suggests that paeoniflorin's protective effects on brain astrocytes may be mediated by TSPO and neurosteroids biosynthesis.
269 citations
,
May 2002 in “Journal of Neuroscience” This study observed that acute stress in rats increased neurosteroid levels linked to enhanced GABA(A) receptor function, raising seizure thresholds, while similar effects were seen in mice with deoxycorticosterone administration.
4 citations
,
July 1979 in “Journal of the American Academy of Dermatology” This study describes "alarm reaction" histologic changes in pilosebaceous structures, including regression of hair matrix and alterations in sebaceous glands, affecting follicular and sebaceous gland morphology.
2 citations
,
November 2024 in “International Journal of Pharmaceutics X” In this study, desmopressin-loaded elastic liposomes (ODEL1) showed improved permeation and drug deposition across rat skin by altering the skin's cohesive energies and causing reversible changes on its surface.
38 citations
,
November 2020 in “International journal of biochemistry & cell biology” This review discusses the biological roles and diagnostic significance of keratins in mammalian colon epithelial cells and reports no new clinical results.
18 citations
,
December 1992 in “Journal of Cutaneous Pathology” This study observed that lectin-binding patterns in skin appendage tumors reveal differences in sweat gland tumors compared to normal tissues, but pilosebaceous tumors maintained a similar lectin-binding pattern to their corresponding normal structures.
37 citations
,
January 2015 in “Evidence-based Complementary and Alternative Medicine” This study found that Bokusoku extract and its compound pentagalloyl glucose inhibited testosterone metabolism and sebum synthesis, suggesting potential therapeutic use for androgen-related acne.
1 citations
,
February 1991 in “Journal of Biological Chemistry”
50 citations
,
September 2014 in “Stem cell reports” In this study, BLIMP1 was found to function in terminally differentiated epidermal cells to maintain homeostasis, rather than defining a sebocyte progenitor population.
April 2019 in “Journal of Investigative Dermatology” This study found that DPP4 is significantly involved in matrix deposition and fibrosis in human skin fibroblasts, although the exact functions of DPP4 remain unclear.