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    Glossary Antiandrogenic

    substances inhibit male sex hormones like testosterone

    Antiandrogenic refers to substances or treatments that inhibit the effects of androgens, which are male sex hormones like testosterone. These substances can be used to treat conditions like androgenic alopecia (hair loss) and prostate cancer by blocking the action of these hormones, thereby reducing their influence on hair follicles and other tissues.

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    1. Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships Current Medicinal Chemistry · 2000 · 204 citations
    2. Treatment of female pattern hair loss with oral antiandrogens British Journal of Dermatology · 2005 · 179 citations
    3. Antiandrogens for the Treatment of Hirsutism: A Systematic Review and Metaanalyses of Randomized Controlled Trials 2008 · 150 citations
    4. Pharmacology of antiandrogens Journal of Steroid Biochemistry · 1986 · 97 citations
    5. Treatment of hirsutism: comparisons between different antiandrogens with central and peripheral effects Fertility and sterility · 1999 · 75 citations
    6. A comparison of the relative efficacy of antiandrogens for the treatment of acne in hyperandrogenic women Clinical Endocrinology · 2002 · 74 citations
    7. ANTIANDROGEN TREATMENT OF POLYCYSTIC OVARY SYNDROME Endocrinology and Metabolism Clinics of North America · 1999 · 52 citations
    8. BIOLOGICAL ACTIVITY OF ANTIANDROGENS 1970 · 51 citations
    9. The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells Nature Communications · 2021 · 50 citations
    10. Mixed “Antiandrogenic” Chemicals at Low Individual Doses Produce Reproductive Tract Malformations in the Male Rat Toxicological sciences · 2018 · 49 citations
    11. Testosterone metabolism in the skin. A review of its function in androgenetic alopecia, acne vulgaris, and idiopathic hirsutism including recent studies with antiandrogens Archives of Dermatology · 1975 · 43 citations
    12. Androgens and Antiandrogens Annals of the New York Academy of Sciences · 2003 · 41 citations
    13. Early Antiandrogen Therapy With Dutasteride Reduces Viral Shedding, Inflammatory Responses, and Time-to-Remission in Males With COVID-19: A Randomized, Double-Blind, Placebo-Controlled Interventional Trial (EAT-DUTA AndroCoV Trial – Biochemical) Cureus · 2021 · 41 citations
    14. Antiandrogens: Clinical applications The Journal of Steroid Biochemistry and Molecular Biology · 1990 · 39 citations
    15. ANTIANDROGEN AND HORMONAL TREATMENT OF ACNE Dermatologic Clinics · 1996 · 38 citations
    16. Evaluation of the rodent Hershberger assay using three reference endocrine disrupters (androgen and antiandrogens) Reproductive Toxicology · 2003 · 37 citations
    17. Effects of Prenatal Treatment with Antiandrogens on Luteinizing Hormone Secretion and Sex Steroid Concentrations in Adult Spotted Hyenas, Crocuta crocuta1 Biology of Reproduction · 2002 · 37 citations
    18. Evaluation of 5α-reductase inhibitory activity of certain herbs useful as antiandrogens Andrologia · 2013 · 33 citations
    19. The Development and Evaluation of An Ovulation Inhibitor (Diane®) Containing An Antiandrogen Acta obstetricia et gynecologica Scandinavica · 1979 · 33 citations
    20. ANTIANDROGEN THERAPY IN DERMATOLOGY International Journal of Dermatology · 1996 · 32 citations
    21. A systematic review of antiandrogens and feminization in transgender women Clinical endocrinology · 2020 · 31 citations
    22. Clinical applications of antiandrogens Journal of Steroid Biochemistry · 1988 · 29 citations
    23. Is There a Role for Antiandrogen Therapy for Hidradenitis Suppurativa? A Systematic Review of Published Data American Journal of Clinical Dermatology · 2019 · 27 citations
    24. The effect of the antiandrogen IIα-hydroxyprogesterone on sebum production and cholesterol concentration of sebum British Journal of Dermatology · 1982 · 27 citations
    25. Testosterone-stimulated weanlings as an alternative to castrated male rats in the Hershberger anti-androgen assay Regulatory Toxicology and Pharmacology · 2004 · 25 citations
    26. Pharmacological basis for clinical use of antiandrogens 1983 · 24 citations
    27. Antiandrogen Therapy for Skin and Hair Disease Dermatologic Clinics · 2006 · 20 citations
    28. 5α-Reductase Inhibitory Components as Antiandrogens From Herbal Medicine Journal of acupuncture and meridian studies · 2010 · 19 citations
    29. Solubilities of Flutamide, Dutasteride, and Finasteride as Antiandrogenic Agents, in Supercritical Carbon Dioxide: Measurement and Correlation Journal of Chemical & Engineering Data · 2009 · 19 citations
    30. Do Anti-androgens Have Potential as Therapeutics for COVID-19? Endocrinology · 2021 · 18 citations