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Polycystic Ovary Syndrome should be seen mainly as a condition of excess male hormones, with a focus on this in its definition.

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

Most women with excess male hormones have Polycystic Ovary Syndrome, and hormonal therapy can improve symptoms but may cause side effects.

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Experts recommend using evidence-based methods to diagnose and treat hirsutism, focusing on symptoms and underlying causes.

Most women referred for excess male hormone symptoms had polycystic ovary syndrome (PCOS), with other conditions being less common.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

Exposure to too much androgen before birth might cause polycystic ovary syndrome later in life.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Androgen deprivation therapy for prostate cancer can cause sexual, physical, and psychological side effects, and doctors should manage these carefully.

Cells from balding scalps have more androgen receptors than cells from non-balding scalps.

Mutations at Val-889 and Arg-752 disrupt key interactions in the androgen receptor, affecting its function.

ERG increases SOX9, promoting prostate cancer growth and invasion.

MK-0773 safely increased muscle mass but did not improve muscle strength or function in elderly women with sarcopenia.

Blocking testosterone speeds up wound healing in males.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Sebocytes play a key role in controlling androgen levels in human skin.

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.

Shorter CAG repeats may cause hair and skin issues, while longer ones may link to acne.

Five new mutations in the androgen receptor gene were found, helping to understand androgen insensitivity syndrome better.

Male hormones promote hair cell growth by using a growth factor from nearby skin cells.

High androgen levels in young women with PCOS are linked to higher blood pressure.

DHT in the human prostate is produced through multiple pathways, not just from testosterone.

Hormonal interactions, especially involving DHT and estrogen, play a key role in BPH development and treatment.

Too much androgen can cause hair loss; finasteride may help.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.