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Non-classical 21 hydroxylase deficiency is an underdiagnosed cause of female hair loss and polycystic ovarian syndrome.

High doses of cyproterone acetate increase the risk of brain tumors in women, but the risk decreases after stopping the medication.

Finasteride-treated male rats' offspring had altered glucose metabolism, potentially increasing diabetes risk.

The new anti-acne treatment HA-P5 effectively reduces acne by targeting two key receptors and avoids an enzyme that can hinder treatment.

Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.

Too much androgen can cause hair loss; finasteride may help.

Blocking the FGF5 gene in sheep leads to more fine wool and active hair follicles due to changes in certain cell signaling pathways.

Androgens, like DHT, affect hair growth and treatments like finasteride may help.

Exposure to too much androgen before birth might cause polycystic ovary syndrome later in life.

Blocking the prolactin receptor might help treat various diseases, but more research is needed.

Finasteride helps treat skin issues like acne and baldness by blocking testosterone conversion.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

Experts recommend using evidence-based methods to diagnose and treat hirsutism, focusing on symptoms and underlying causes.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

MC4R gene variants not linked to female hair loss.

A protein called ectodysplasin-A2 increases a hair growth inhibitor in balding cells, which could be a target for hair loss treatment.

Removing part of the vitamin D receptor stops vitamin D from working properly.

DHT is a strong androgen that may pose less risk to the prostate compared to testosterone.

Identifying nonclassic congenital adrenal hyperplasia and carriers of CYP21 mutations is challenging, and genetic counseling is recommended due to their prevalence.

The conclusion is that accurately identifying the cause of high androgen levels in women with PCOS is crucial and requires specific tests.

Researchers found genetic mutations causing hypohidrotic ectodermal dysplasia in 88% of studied patients and identified new mutations and genetic variations affecting the disease.

Certain genetic variations are linked to increased androgen levels in PCOS, but more research is needed to understand these connections fully.

Two women with very high androgen levels had only slight skin issues, one due to a non-classical adrenal disorder and the other due to an adrenal tumor.

Excessive body hair in women can be caused by various conditions and treated with medication like Diane® 35 or androgen blockers.

Genetic mutations can affect female sexual development, requiring personalized medical care.

The girl's unexpected pubic hair growth led to a diagnosis different from complete androgen insensitivity syndrome.

Jumonji genes are important for development and their mutations can cause abnormalities, especially in the heart and brain.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Most hirsutism cases are due to PCOS, and treatment focuses on lowering testosterone and blocking its effects.