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Pfizer found that pantolactam-based compounds can reduce sebum (skin oil) production when applied topically.

FGF9 controls which receptors it binds to through a process where two FGF9 molecules join, and changes in FGF9 can lead to incorrect receptor activation.

Dexamethasone increases the activity of androgen receptors in human skin cells, which may link it to certain types of hair loss.

Early hormones shape sex-specific differences in rat glands.

Understanding how androgens and their receptors work can lead to improved treatments for skin diseases.

A new genetic change causing early stop in the androgen receptor gene was found in a patient with androgen insensitivity syndrome.

Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.

Certain genes and X chromosome patterns may significantly contribute to the development of hair loss.

Sebocytes play a key role in controlling androgen levels in human skin.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

The document concludes that treating androgen excess needs patience, managing expectations is important, and many drugs used are not officially approved, suggesting cosmetic options for mild cases.

Certain compounds from Panax ginseng can block proteins that affect hair growth, potentially helping treat hair loss.

COVID-19 may worsen with androgens; anti-androgen drugs could help.

The more lipophilic the progesterone derivative, the better it binds to androgen receptors and has antiandrogenic effects.

Betacoronaviruses, like COVID-19, may cause hormone system dysfunction and affect disease susceptibility and severity.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

The document explains how male reproductive hormones work and affect the body.

Androgens can help prevent memory problems caused by apoE4.

The drug enzalutamide may reduce the ability of the virus causing COVID-19 to enter lung cells.

Men with Kennedy disease have less chance of hair loss.

New treatments for enlarged prostate are being developed to be more effective and have fewer side effects.

Different drugs can treat high male hormone levels in women, but they have various effects and some may harm a fetus.

Hormonal contraceptives can help treat acne by affecting sebum production and androgen levels.

Vitamin D receptor binds similarly to natural and synthetic ligands, affecting gene regulation.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

Scientists found new nonsteroidal compounds that can act like natural male hormones and might help treat male fertility and hormone issues.

Proxalutamide significantly lowered hospital admissions for male COVID-19 patients compared to a placebo.