research Determination of Rat 5α-Reductase Type 1 Isozyme Activity and Its Inhibition by Novel Steroidal Oxazolines
New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.
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research Three-Dimensional Proteome-Wide Scale Screening for the 5-Alpha Reductase Inhibitor Finasteride: Identification of a Novel Off-Target
Finasteride may affect PNMT, causing side effects.
research Evaluation of Bioequivalence of Five 0.1 mg Dutasteride Capsules Compared to One 0.5 mg Dutasteride Capsule: A Randomized Study in Healthy Male Volunteers
Taking five small dutasteride capsules is the same as taking one larger capsule.
research Clinical Use of 5α-Reductase Inhibitors
Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.
research A Phase 1 Study to Investigate the Effects of Cortexolone 17α-Propionate, Also Known as Clascoterone, on the QT Interval Using the Meal Effect to Demonstrate ECG Assay Sensitivity
Clascoterone is safe for the heart, even at high doses.
research Terazosin or Baclofen in Young Men with Chronic Orchialgia: A Cohort Study of 499 Patients
Both terazosin and baclofen effectively reduce pain in young men with chronic testicular pain, with no difference in their effectiveness.
research Epidemiological Assessment of Testosterone Levels in Women: A Factorial Analysis of Cell Proliferation
High testosterone levels in 20% of the women studied may indicate PCOS, while 80% had low levels with potential health impacts.
research High-Value Dermatology: Five Laboratory Tests to Reconsider
The article suggests that five common skin-related lab tests may be unnecessary and could cause extra cost and anxiety without improving patient care.
research Polycystic Ovary Syndrome: Comprehensive Management and Health Impacts
PCOS is a common hormonal disorder in women that can lead to various health issues and requires comprehensive management.
research Genetic Analysis of 5 Alpha Reductase Type 2 Enzyme in Relation to Oxidative Stress in Cases of Androgenetic Alopecia in a Sample of Egyptian Population
5α reductase type 2 enzyme mutation and oxidative stress may increase androgenetic alopecia risk in Egyptians.
research Researchers Link Early Hair Loss and Prostate Cancer
Early hair loss may increase the risk of prostate cancer, especially in African American men and those with frontal baldness.
research The Pathogenesis of Acne: How Might Azelaic Acid Act?
Azelaic acid may help treat acne by killing bacteria, reducing inflammation, and preventing clogged pores.
research Cyproterone Acetate: A Genotoxic Carcinogen?
Cyproterone acetate may cause liver cancer at high doses, but is considered safe at recommended doses for approved uses.
research Type A Insulin Resistance Syndrome Due to a Novel Heterozygous c.3486_3503del (p. Arg1163_Ala1168del) INSR Gene Mutation in an Adolescent Girl and Her Mother
A new gene mutation causes insulin resistance in a girl and her mother.
research Analytical Methods of Dutasteride: An Overview
Dutasteride is more effective than finasteride for hair loss treatment.
research The Laboratory in the Multidisciplinary Diagnosis of Differences or Disorders of Sex Development (DSD)
Diagnosing sex development disorders requires combining medical history, physical exams, imaging, lab tests, and genetic data.
research Triple Hormonal Blockade (ADT3): A Patient’s Perspective
Triple Hormonal Blockade (ADT3) can effectively manage prostate cancer but requires careful monitoring for heart risks.
research Glossary
research Primary Generalized Glucocorticoid Resistance or Chrousos Syndrome: Allostasis Through a Mutated Glucocorticoid Receptor
Chrousos Syndrome is caused by mutations that make the body less sensitive to glucocorticoids, leading to various symptoms and requiring high-dose treatment.
research Female Sexual Dysfunction: Prevalence, Causes, and Treatments
Many women experience sexual dysfunction, but few seek help, and better treatment and medical training are needed.
research Reduction of Diameter of Hair Shaft Among Women With Hirsutism
Aldactone effectively reduces hair thickness in women with excessive hair growth, both alone and with other treatments.
research Reduction of Diameter of Hair Shaft Among Women With Hirsutism
Spironolactone effectively makes hair shafts thinner in women with excessive hair growth.
research Impact of Ustekinumab on Quality of Life and Sexual Difficulties Associated with Psoriasis: Results from Phase III Clinical Trials
Ustekinumab significantly improved sexual function and quality of life for people with moderate to severe psoriasis.
research Incidence of Serious Infectious Events with Methotrexate Treatment: Meta-Analysis of Randomized Controlled Trials
Methotrexate treatment for rheumatoid arthritis has a serious infection rate of about two per 100 patient-years.
research Effects of Parthenolide on Androgenetic Alopecia in Mice and Human Follicle Dermal Papilla Cells
Parthenolide promotes hair growth in mice and may influence pathways related to male pattern baldness.
research Polycystic Ovarian Syndrome and Obstructive Sleep Apnea
Women with PCOS are much more likely to have sleep problems and should be checked for them.
research Crystal Structure and Synthesis of 17α-Acetoxy-4-Bromopregn-4-Ene-3,20-Dione
The document concludes that a compound with potential for treating prostate cancer and hair loss was successfully made and its detailed structure was confirmed.
research Urinary Steroid Analysis of Women with Effluvium
Women with effluvium have higher levels of certain urinary steroids, possibly due to stress and increased adrenal activity.
research A Study of the Effects of Topical Minoxidil in the Treatment of Androgenic Alopecia Using Phototrichograms
Minoxidil helps increase hair growth and density in people with hair loss, with higher concentrations giving better results.
research The Role of Vitamin E in the Management of Polycystic Ovarian Syndrome
Vitamin E helps reduce PCOS symptoms and improves hormonal balance.