Incidence of Serious Infectious Events with Methotrexate Treatment: Meta-Analysis of Randomized Controlled Trials

The document presents findings from various studies on different medical conditions. One study involving 160 white females assessed insulin resistance and endothelial function in women with idiopathic hirsutism (IH) and polycystic ovary syndrome (PCOS). It found that nonobese women with PCOS had significantly higher basal insulin levels and HOMA scores compared to those with nonobese IH and controls. Another study with 50 patients explored the relationship between androgenetic alopecia (AGA) and urinary symptoms related to benign prostatic hyperplasia. It found that men with early-onset AGA had larger prostate volumes and more urinary symptoms than controls. A third study on 1996 patients with psoriasis treated with ustekinumab showed significant improvement in sexual function and quality of life. Lastly, a meta-analysis of randomized controlled trials aimed to estimate the incidence of serious infectious events (SIEs) with methotrexate treatment for psoriasis, psoriatic arthritis, and rheumatoid arthritis. It concluded that the rate of SIEs in rheumatoid arthritis was approximately two per 100 patient-year exposures, which is consistent with previous observational studies. The document does not provide a conclusion for the methotrexate meta-analysis in psoriasis and psoriatic arthritis due to limited data.