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The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

Older women face various skin issues like dryness and thinning, and treatments are available but can have side effects; proper skin care and legal health decisions are important.

Women with nonclassic congenital adrenal hyperplasia experience more sexual dysfunction and distress.

The document concludes that hormone therapy is essential for treating gender dysphoria, with specific drugs and monitoring protocols recommended for safety and effectiveness.

5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.

Women with PCOS have more depression and stress due to high androgen levels, not obesity or insulin resistance.

PCOS treatment focuses on lifestyle changes and specific medications to manage symptoms and complications.

Diagnosing and treating PCOS is complex due to differing criteria and requires a team approach.

PCOS treatment should address both symptoms and metabolic risks, starting with lifestyle changes and possibly including medication.

Primary care is key in managing PCOS, focusing on lifestyle changes and medications like birth control and metformin.

Statins may help treat PCOS by lowering androgen levels and improving cholesterol.

Minoxidil may work for hair loss by reducing androgen sensitivity and altering hormone-related enzymes.

Proxalutamide improved recovery, lowered death rates, and reduced hospital stay for COVID-19 patients.

Spironolactone is safe for treating female hair loss, but the safety of other drugs is uncertain.

Women with Polycystic Ovary Syndrome (PCOS) have lower levels of a substance called DIAPH1 in their blood, which is linked to changes in sugar metabolism and insulin resistance.

The research found that male pattern hair loss is mostly genetic and involves hair thinning due to hormonal effects and changes in gene expression.

Topical finasteride might be a good alternative for hair loss treatment with fewer side effects, but more research is needed.

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

Muscles can make their own androgens, which may help muscle growth.

Polycystic ovary syndrome increases the risk of diabetes, heart disease, and endometrial cancer, and requires early treatment to manage these risks.

Sex hormones may influence COVID-19 severity, with males at higher risk, and certain hormone therapies could potentially treat the virus.

Retinoic acid affects male and female muscle energy use and function differently.

Acne is strongly linked to high BMI, hair loss, menstrual issues, family history, and eating too many sweets and fatty foods, but not to excessive hair growth.

Dutasteride may help protect neurons and reduce inflammation in Parkinson's disease.

Cirrhosis affects quality of life with various symptoms, requiring a holistic, multidisciplinary approach for management.

Certain genes may influence hair loss differently in men and women.

Metformin lowers prolactin in women without PCOS but not in those with PCOS, where it reduces other hormones instead.

New treatments for hair loss should target eight main causes and use specific plant compounds and peptides for better results.

The conclusion is to diagnose PCOS with just hyperandrogenism and irregular periods, and treat with lifestyle changes and basic medications.

Three siblings with a rare genetic condition had abnormal sexual development and chose different gender identities, needing surgery and therapy.