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Glossary Androgenic Disorders

refer to conditions caused by abnormal male hormone activity

Androgenic disorders refer to medical conditions caused by the abnormal production or action of androgens, which are male sex hormones like testosterone. These disorders can lead to various symptoms, including excessive hair growth (hirsutism) in women, hair loss (androgenic alopecia) in both men and women, and other hormonal imbalances that can affect reproductive and overall health.

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research Dietary Phytochemicals and their Impact on Androgen Disorders in Males

May 2025 in “IDOSR JOURNAL OF BIOLOGY CHEMISTRY AND PHARMACY”

This review explores current research on how dietary phytochemicals may help manage male androgen disorders by affecting hormone levels and endocrine function, highlighting their potential therapeutic roles and mechanisms in hormonal health, but does not report specific results.

research The Interplay between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation

October 2022 in “Biomedicines”

In this rat study, offspring from females fertilized by finasteride-treated males showed hyperglycemia and increased hepatic glycogen, linking paternal androgen imbalance to liver issues across generations.

research Androgen excess disorders remain undiagnosed in one of every four premenopausal women with Type 1 diabetes

January 2025 in “Human Reproduction Open”

This study found that approximately 26% of women with Type 1 diabetes have undiagnosed androgen disorders, with polycystic ovary syndrome being the most common, particularly in those with premenarcheal onset of diabetes.

research Hormonal Treatment for Skin Androgen-Related Disorders

January 2015

Hormonal treatments can help with hair loss, acne, and excess hair growth, but it takes 3-6 months to see results and patients should know the possible side effects.

research Is acne a sign of androgen excess disorder or not?

21 citations , January 2017 in “European Journal of Obstetrics & Gynecology and Reproductive Biology”

This study suggests that acne is often associated with hyperandrogenemia in women, contradicting previous recommendations that acne is not linked to androgen excess disorders.

research The Role of 11-Oxygenated Androgens and Endocrine Disruptors in Androgen Excess Disorders in Women

7 citations , September 2024 in “International Journal of Molecular Sciences”

This study found that 11-oxygenated androgens were higher in women with PCOS compared to those with idiopathic hirsutism, with no difference from controls, and higher Bisphenol A levels in obese women with PCOS may worsen metabolic issues.

research Androgen-related disorders and hormone therapy for patients with keloids

3 citations , March 2022 in “Chinese Journal of Plastic and Reconstructive Surgery”

This review discusses the potential role of androgen-related disorders in keloid pathogenesis and highlights the need for systemic treatments targeting sex hormones, but reports no new clinical results.

research Disorders linked to insufficient androgen action in male children

111 citations , May 2001 in “Human reproduction update”

This review discusses the role of genetic mutations and environmental endocrine disruptors in insufficient androgen action, which can result in conditions like hypospadias, cryptorchidism, and micropenis, during male fetal development.

research Defects in Androgen Biosynthesis Causing 46,XY Disorders of Sexual Development

46 citations , October 2012 in “Seminars in reproductive medicine”

This review describes how recent discoveries in genetic defects and alternative pathways in androgen biosynthesis are reshaping our understanding of male sexual differentiation, but it presents no new clinical findings.

research Disorders linked to insufficient androgen action in male children

July 2001 in “APMIS. Acta pathologica, microbiologica et immunologica Scandinavica./APMIS”

This article reviews the potential causes of insufficient androgen action during fetal development, such as enzyme and receptor gene mutations or environmental disruptors, but reports no new results.

research Prevalence of functional disorders of androgen excess in unselected premenopausal women: a study in blood donors

70 citations , February 2012 in “Human Reproduction”

This study found a high prevalence of clinical signs and functional disorders of androgen excess in premenopausal women, with idiopathic hyperandrogenism and idiopathic hirsutism rates similar to PCOS.

research Dermatology of androgen-related disorders

67 citations , July 2006 in “Clinics in Dermatology”

This review discusses the dermatologic manifestations of hyperandrogenism in women and outlines the diagnostic approach and treatment options, reporting no new clinical results.

research Hidradenitis suppurativa: an-androgen-dependent disorder

49 citations , September 1986 in “British Journal of Dermatology”

Hidradenitis suppurativa improves with antiandrogen therapy.

Increased Scalp Skin and Serum 5a-Reductase Reduced Androgens in a Man Relevant to the Acquired Progressive Kinky Hair Disorder and Developing Androgenetic Alopecia

research Increased Scalp Skin and Serum 5a-Reductase Reduced Androgens in a Man Relevant to the Acquired Progressive Kinky Hair Disorder and Developing Androgenetic Alopecia

11 citations , September 1997 in “Archives of Dermatology”

Reduced androgens linked to kinky hair disorder and hair loss; 5a-reductase inhibitors may help.

Benign Prostatic Hyperplasia: A Disorder of Androgen Metabolism in Males

research Benign Prostatic Hyperplasia: A Disorder of Androgen Metabolism in the Male

23 citations , May 1984 in “Journal of the American Geriatrics Society”

Benign Prostatic Hyperplasia may be caused by changes in how the body processes male hormones.

research Role of 5α-reductase inhibitors in androgen-stimulated skin disorders.

3 citations , February 2013 in “PubMed”

This review discusses the pathophysiology of androgen-stimulated skin disorders and key clinical trials of 5α-reductase inhibitors for their treatment, but it does not report new clinical results.

research Skin Androgen-Related Disorders: Hormonal Treatment

1 citations , January 2023

research Relative Prevalence of Different Androgen Excess Disorders in 950 Women Referred because of Clinical Hyperandrogenism

352 citations , January 2006 in “The Journal of Clinical Endocrinology and Metabolism”

This study reported that classic anovulatory PCOS was the most common androgen excess disorder, followed by mild ovulatory PCOS and idiopathic hyperandrogenism, among patients evaluated for clinical hyperandrogenism.

research Endocrinology of Hirsutism: From Androgens to Androgen Excess Disorders

20 citations , January 2019 in “Frontiers of Hormone Research”

This paper reviews the endocrinological aspects of hirsutism, focusing on the role of androgens in excessive hair growth and the related disorders, without presenting new findings.

Sexual Function in Women with Androgen Excess Disorders: Classic Forms of Congenital Adrenal Hyperplasia and Polycystic Ovary Syndrome

research Sexual function in women with androgen excess disorders: classic forms of congenital adrenal hyperplasia and polycystic ovary syndrome

5 citations , June 2020 in “Journal of Endocrinological Investigation”

The study observed that women with congenital adrenal hyperplasia experience more impaired sexual functions and are more often homosexually or bisexually oriented than those with polycystic ovary syndrome.

research The role of androgen and androgen receptor in skin-related disorders

124 citations , July 2012 in “Archives of Dermatological Research”

This review discusses the roles of androgens and androgen receptors in skin-related disorders and suggests that targeting androgen receptors may be a more effective treatment strategy.

research Animal models of androgen-dependent disorders of the pilosebaceous apparatus

38 citations , July 1989 in “Archives of dermatological research”

Testosterone causes hair loss in AGA mice, which are good for testing baldness treatments, and both minoxidil and cyproterone acetate can prevent this hair loss.

research Polycystic ovary syndrome patients with high BMI tend to have functional disorders of androgen excess: a prospective study

23 citations , January 2016 in “Journal of Nanjing Medical University”

This study found that higher BMI in PCOS patients at a Chinese clinic was associated with functional disorders of androgen excess, suggesting BMI may predict hyperandrogenism in this population.

Androgens in Women: Critical Evaluation of Methods for Their Determination in Diagnosing Endocrine Disorders

research Androgens in Women – Critical Evaluation of the Methods for Their Determination in Diagnostics of Endocrine Disorders

10 citations , November 2018 in “Physiological Research”

This review examines the methods and challenges in androgen laboratory diagnostics, discussing their advantages, limitations, and evolution; it presents no new experimental results.

research Anti-Androgen Drugs in the Treatment of Obsessive-Compulsive Disorder: A Systematic Review

1 citations , December 2019 in “Current Medicinal Chemistry”

This study found that anti-androgens may reduce OCD symptoms, but the evidence is of low quality and further large, randomized trials are needed.

research Finasteride reduces the preventive effect of uroselective α1A-blockers against cancellous bone disorders induced by androgen deficiency in rats

July 2015 in “Pharmacological Reports”

Finasteride weakens the bone-protective effects of certain blockers in low androgen conditions.

research SRD5A2 and emerging therapies in androgen-driven disorders

January 2026 in “Nature Reviews Urology”

research Keyora Integrated Nutritional Modulation of the Redox–NO–Androgen Axis in Male Endocrine, Reproductive, and Metabolic Disorders

January 2025 in “Open Science Framework”

The project aims to validate a nutritional intervention targeting the Redox–NO–Androgen Axis to restore mitochondrial, endothelial, and hormonal balance in male health disorders related to oxidative stress.

research Increased scalp skin and serum 5 alpha-reductase reduced androgens in a man relevant to the acquired progressive kinky hair disorder and developing androgenetic alopecia

2 citations , September 1997 in “Archives of Dermatology”

research Worldwide cohort study of 46, XY differences/disorders of sex development genetic diagnoses: geographic and ethnic differences in variants

13 citations , June 2024 in “Frontiers in Genetics”

This review examined genetic factors in 46, XY differences/disorders of sex development and found that whole-exome sequencing is more effective than panel sequencing for molecular diagnosis. It identified regional genetic variation and emphasized next-generation sequencing's role in detecting variants related to gonadal and androgen-related genes.