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Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Interferon alfa-2a is effective for treating cutaneous T cell lymphoma but has significant side effects.

Pregnancy can cause various skin changes and diseases, with PUPPP being the most common skin condition specific to pregnancy.

A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.

Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.

Menopause can lead to skin and hair problems due to hormonal changes, but hormone replacement therapy might help slow these effects.

Stem cell niches support, regulate, and coordinate stem cell functions.

Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Estrogen replacement can improve skin health in menopausal women but doesn't reverse sun damage or prevent hair loss.

Estrogen loss during menopause worsens skin health, but hormone replacement therapy may improve it, though more research is needed.

Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.

Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

Testosterone treatment in trans men increases body and facial hair and may lead to hair loss over time, but severe skin issues are rare.

Flutamide may slightly improve hair loss in women, but finasteride does not work.

New treatments for Alopecia Areata show promise but need to be more effective and affordable.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

Spironolactone most effective for hirsutism, but has side effects.

The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.

The document concludes that specific itchy skin diseases during pregnancy have varying fetal risks and treatments, including corticosteroids and other medications.

Skin changes can help diagnose and manage endocrine disorders like thyroid problems, diabetes, and adrenal gland conditions.

The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.

TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.

Spironolactone effectively reduces hair growth in women with hirsutism and is generally well-tolerated.

Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.

The document concludes that accurate measurement of serum androgens is crucial for diagnosing hyperandrogenism.

Acne is a chronic disease linked to various systemic conditions and has significant psychological and social effects.