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Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Estrogen replacement can improve skin health in menopausal women but doesn't reverse sun damage or prevent hair loss.

Estrogen loss during menopause worsens skin health, but hormone replacement therapy may improve it, though more research is needed.

Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.

Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

Testosterone treatment in trans men increases body and facial hair and may lead to hair loss over time, but severe skin issues are rare.

Flutamide may slightly improve hair loss in women, but finasteride does not work.

New treatments for Alopecia Areata show promise but need to be more effective and affordable.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

Spironolactone most effective for hirsutism, but has side effects.

The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.

The document concludes that specific itchy skin diseases during pregnancy have varying fetal risks and treatments, including corticosteroids and other medications.

Skin changes can help diagnose and manage endocrine disorders like thyroid problems, diabetes, and adrenal gland conditions.

The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.

TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.

Spironolactone effectively reduces hair growth in women with hirsutism and is generally well-tolerated.

Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.

The document concludes that accurate measurement of serum androgens is crucial for diagnosing hyperandrogenism.

Acne is a chronic disease linked to various systemic conditions and has significant psychological and social effects.

Dermal papilla cells help wounds heal better and can potentially grow new hair.

Estrogens and SERMs can help with skin aging, but their safety and effectiveness need more research.

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.

Hair follicle stem cells are a promising source for tissue repair and treating skin or hair diseases.

Light can turn on hair growth cells through a nerve path starting in the eyes.

Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.

Research on epidermal stem cells has advanced significantly, showing promise for improved clinical therapies.

Antidepressants called SSRIs can cause skin problems, bleeding risk, and other side effects.

Stem cells help repair tissue mainly by releasing beneficial substances, not by replacing damaged cells.