January 2026 in “Dermatology Practical & Conceptual” This study observed that 78.3% of patients with alopecia areata exhibited nail changes detectable by dermoscopy, notably nail pitting, in contrast to 14.2% of healthy controls, with these changes significantly associated with disease severity, age, and duration.
December 2021 in “Indian Journal of Dermatology, Venereology and Leprology” In this study, androgenetic alopecia patients exhibited more nailfold capillary abnormalities, suggesting a potential link between microcirculation issues and the condition.
28 citations
,
December 2006 in “Clinical lung cancer” This review outlines various non-rash skin toxicities associated with novel targeted anticancer therapies and provides guidelines for their early diagnosis and management, but reports no new clinical results.
6 citations
,
September 2013 in “The Obstetrician & Gynaecologist” This article reviews the physiological skin changes and unique dermatoses in pregnancy, discussing their causes and management, but reports no new clinical findings.
64 citations
,
June 1992 in “International Journal of Dermatology” Pregnancy often causes skin changes like darkening, stretch marks, and hair growth, which may improve after childbirth.
January 2026 in “Clinical & Translational Oncology” This expert consensus statement highlights that while targeted cancer therapies significantly improve patient survival, they often result in various skin toxicities, underscoring the need for early diagnosis, management, and multidisciplinary care to maintain patients' quality of life and ensure treatment continuity.
38 citations
,
February 2012 in “Supportive Care in Cancer” Skin problems like acne, dry skin, and nail and hair changes are common in patients taking EGFR inhibitors.
1 citations
,
November 2025 in “Journal of Korean Medical Association” This review describes nail changes linked to various non-infectious skin diseases, highlighting how these alterations can help diagnose and manage conditions like psoriasis and lupus by noting specific and overlapping nail characteristics.
25 citations
,
October 2017 in “Clinics in Dermatology” This review discusses common hair and nail diseases in the elderly and reports no new clinical results, noting their significant impact on quality of life.
11 citations
,
January 2017 in “Dermato-endocrinology” This study observed that common skin changes in patients with type 2 diabetes included peripheral hair loss, xerosis, anhydrosis, and nail alterations, underscoring the importance of controlling blood sugar and foot care to prevent neuropathy complications.
2 citations
,
January 2025 in “Dermatology Practical & Conceptual” In this study, dermoscopic examination of COVID-19 patients revealed significant microvascular changes in the proximal nailfold, such as avascular areas and disorganized capillary architecture, compared to healthy controls, with some regression of these changes observed over time.
September 1998 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This paper reviews the diverse skin, nail, and hair changes caused by medications, highlighting hyperpigmentation, alopecia, and nail structural alterations, but reports no new data.
January 2026 in “Advances in Dermatology and Allergology” In this study, researchers observed that patients with alopecia areata showed higher capillary density and signs of neovascularization compared to controls, suggesting a potential link between alopecia areata and microcirculatory changes.
88 citations
,
June 2000 in “Journal of Investigative Dermatology” Keratin 17 is important for hair and nail structure and affects pachyonychia congenita symptoms.
January 2023 in “Indian dermatology online journal” This case report describes a novel NECTIN4 gene mutation linked to ED-syndactyly syndrome 1 in a young girl, contributing to the understanding of this rare ectodermal dysplasia.
41 citations
,
October 2017 in “International Journal of Women's Dermatology” This review provides an overview of the physiologic skin changes during pregnancy but reports no new findings, emphasizing the need for physicians to distinguish between benign and potentially pathological conditions.
March 2015 in “Polish Journal of Public Health” This study found that capillaroscopic patterns varied among patients with systemic scleroderma, psoriasis, psoriatic arthritis, and alopecia, suggesting potential microcirculation disturbances; however, no correlations were observed with serum angiogenic markers.
October 2023 in “Case reports in dermatological medicine” In this case report, a 45-year-old Jordanian woman was diagnosed with Clouston syndrome, an autosomal-dominant disorder characterized by alopecia and nail dystrophy due to a mutation in the GJB6 gene, though she lacked the typical palmoplantar keratoderma.
May 2023 in “Journal of The American Academy of Dermatology” This source reports that pregnancy leads to significant changes in skin physiology, including hyperpigmentation, hair and nail alterations, vascular modifications, and glandular shifts, highlighting the complex physiological adjustments during this period.
47 citations
,
May 2002 in “Journal of Cutaneous Medicine and Surgery” This review discusses normal skin changes during pregnancy such as pigmentary and glandular alterations, highlighting the need for physician awareness to avoid unnecessary treatments, and reports no new clinical findings.
53 citations
,
January 1953 in “The journal of nutrition/The Journal of nutrition” This study found that newborn mice deprived of colostrum developed disorders linked to zinc deficiency, and administering inorganic zinc prevented these conditions.
141 citations
,
January 1984 in “Journal of The American Academy of Dermatology” This review discusses skin changes during pregnancy, highlighting both pregnancy-specific and common physiologic changes, but reports no new clinical findings.
71 citations
,
February 2006 in “Clinics in Dermatology” This review discusses the physiological skin changes during pregnancy and reports no new clinical results, emphasizing the importance of distinguishing these changes from pathological conditions.
13 citations
,
June 1984 in “Postgraduate Medicine” This article discusses various pruritic dermatoses that can occur during pregnancy, emphasizing the importance of physician skill in diagnosing and treating these conditions; it reports no new findings.
20 citations
,
October 2003 in “The Journal of Dermatology” This study observed that while dexamethasone-cyclophosphamide pulse therapy is relatively free from hypertension and diabetes compared to conventional steroids in pemphigus patients, it frequently causes generalized weakness and flushing.
February 2009 in “Springer eBooks” Pregnancy can cause more body and scalp hair growth and make nails brittle, but these changes often revert after giving birth.
21 citations
,
January 2005 in “Skinmed” This article reviews the structural similarities and common disorders of hair and nails, highlighting their joint involvement in congenital and acquired conditions, but it reports no new clinical results.
18 citations
,
March 2004 in “Clinics in Dermatology” This review discusses recent advances in understanding the cellular, molecular, and genetic factors contributing to lupus erythematosus and reports no new experimental findings.
10 citations
,
April 2019 in “Environmental Science and Pollution Research” In this study, selenium-rich diets enhanced antioxidant activity in aged mice, suggesting potential biological benefits, although further trials are needed to fully understand long-term risks and benefits.
8 citations
,
May 2021 in “Journal of the European Academy of Dermatology and Venereology” This case report describes a 23-year-old male patient with nail discoloration that may be associated with COVID-19, suggesting possible microvascular damage.