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Researchers created a model to understand heart aging, highlighting key genes and pathways, and suggesting miR-208a as a potential heart attack biomarker.

Tacrolimus causes fewer acute rejections than cyclosporin A in kidney transplants but doesn't necessarily improve kidney function after one year; cardiovascular risks and side effects vary between the two drugs.

The gene Prss53 affects hair shape and bone development in rabbits.

Some medications caused temporary health issues that improved after stopping the drugs, but two patients died from liver problems linked to carbamazepine.

Tamsulosin may slightly increase dementia risk compared to other treatments for enlarged prostate.

Treatments for enlarged prostate can cause problems with ejaculation, and less invasive options might preserve sexual function better.

Testosterone replacement is recommended for men with low testosterone levels and symptoms of hypogonadism.

Most patients treated with low-dose alpha-interferon for malignant melanoma experienced skin side effects, with hair loss being the most frequent.

Thiourea compounds affect hair growth and pigmentation in black rats.

Human alpha defensin 5 helps heal wounds, reduce bacteria, and grow hair on burned skin.

Injecting alpha-melanocyte-stimulating hormone in mice improved skin healing and reduced scarring.

Alpha Lipoic Acid helps protect skin from smoking damage.

A mix of Platycladus orientalis leaf extract and alpha-terpineol helps mice grow hair by increasing growth factors and cell growth.

TRP-hair essence protects hair from heat damage, maintains color, and strengthens hair.

5-alpha reductase inhibitors slightly reduce urinary symptoms and may lower surgery and acute retention risks in men.

Vitamin E affects liver metabolism, enhancing stress resistance, reducing blood clotting, and altering hormone processing.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

High levels of 3 alpha-diol glucuronide in the blood are a marker of increased androgen action in women with excessive hair growth of unknown cause.

The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.

New compounds called benzoquinolinones may treat conditions linked to excess DHT.

Finasteride works better than Permixon in reducing dihydrotestosterone levels.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.

Finasteride, when given in high oral doses to pregnant monkeys, caused genital abnormalities in male fetuses, but not in female fetuses or those exposed to intravenous finasteride.

Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.

A new drug, dutasteride, is at least as effective as the older drug, finasteride, for treating enlarged prostate and may have additional uses.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

5-alpha-reductase inhibitors can lower prostate cancer risk but may increase high-grade tumors and cause sexual side effects.

Hair lotions with 17 alpha-estradiol can reduce hair loss but won't regrow new hair.