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Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Flutamide combined with an LHRH agonist effectively inhibits prostate growth, suggesting it could treat prostate cancer.

New compounds may soon be tested to treat excessive hair growth in women.

Changing neuroactive steroids in baby male rats affects their memory and learning differently as they grow up.

Cytokines and neuropeptides are key in controlling androgen levels, affecting skin and hair conditions.

Certain HSD3B1 gene types are linked to worse prostate cancer outcomes and affect treatment response and other health conditions.

5α-Reductase inhibitors can help treat hair loss, acne, and prostate issues by reducing DHT levels.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.

Adrenal disorders can cause lasting brain and behavior issues in children.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

Finasteride may affect PNMT, causing side effects.

Using 5-alpha reductase inhibitors may increase the risk of mild depression.

Women with non-classic congenital adrenal hyperplasia have higher risk for heart and metabolic problems.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Men taking 5α-reductase inhibitors for enlarged prostate have a higher chance of experiencing reduced sexual desire and erectile dysfunction.

Researchers found new potential but less potent rat enzyme inhibitors using a 3D model.

New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.

Male yak hair growth is influenced by DHT synthesis, which is promoted by 5α-red1 and AR during growth phases, while E2 may inhibit growth through ERα.

Stress-related hair loss was reversed with a special medication.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Alopecia areata treatment should be personalized, using topical or systemic therapies based on severity, with promising options like JAK inhibitors needing more research.

Androgen conjugates might be better indicators of skin sensitivity to hormones in women with excessive hair growth.