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AIRE-deficient rats developed severe autoimmune disease similar to APECED, useful for testing treatments.

Hormonal changes after childbirth and menopause can lead to women's hair loss and facial hair growth, with a need for better treatments.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.

Birth control pills combined with bicalutamide are more effective at reducing excessive hair growth in women with PCOS than birth control pills alone.

The HGCA tool helps identify genes that work together by analyzing their co-expression patterns.

The document concludes that ongoing research using animal models is crucial for better understanding and treating Alopecia Areata.

Frontal Fibrosing Alopecia's cause is unclear, affects mainly postmenopausal women, and current treatments focus on stopping hair loss rather than regrowth.

New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.

Hair follicle bulge cells don't help skin regrow after glucocorticoid damage; interfollicular epidermis cells do.

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.

The conclusion is that skin and hair patterns are formed by a mix of cell activities, molecular signals, and environmental factors.

Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

COVID-19 may harm male fertility and damage the reproductive system.

Canine epidermal neural crest stem cells could be a promising treatment for spinal cord injuries in dogs.

New markers and pathways have been found in skin tumors, helping better understand and diagnose them.

Wnt7a protein is crucial for development and tissue maintenance and plays varying roles in diseases and potential treatments.

Hair follicles are essential for skin health, aiding in hair growth, wound healing, and immune function.

Hormones and genes affect hair growth and male baldness.

The document concludes that various cosmetic and drug treatments are available for hirsutism, and some new drugs show promise.

Immune checkpoint inhibitors can cause skin issues but are linked to better cancer outcomes.

Removing myelin protein zero-like 3 in mice leads to better metabolism and resistance to obesity.

Melatonin stimulates the skin components of ram's scrotum during their non-breeding season.

Sex hormones, especially estradiol, can change chicken feather shapes and colors.

Thyroid hormones and androgens affect gene expression in frog reproductive organs differently between males and females.

Chemotherapy causes complex changes in hair follicle cells that can lead to hair loss.

Alcohol in teen years leads to more adult drinking, finasteride doesn't help.