Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that diagnosing nonclassic congenital adrenal hyperplasia in women based solely on serum 17OHP measurements can lead to false positives, suggesting the need for urinary steroid profiles and genetic testing for confirmation.

This study found that in patients with nonclassical 21-hydroxylase deficiency, genotypes do not reliably predict the severity of hyperandrogenic symptoms, suggesting other genetic factors may influence the phenotype.

This review discusses the embryology, structure, and function of sebaceous glands and their involvement in skin disorders but reports no novel findings.

This review discusses how androgens, commonly known for male reproductive roles, also influence the physiology and pathology of the human endometrium, though their exact roles in this tissue remain controversial and not fully understood.

In this study, adolescents with depressive symptoms were found to have higher urinary excretion rates of certain steroid metabolites, including corticosterone and adrenal hormones, and a specific metabolite ratio was identified as a potential biomarker for distinguishing these patients from healthy controls.

This case report highlights a rare diagnosis of an androgen-secreting adrenal tumor in a patient with hyperandrogenism and virilization symptoms, emphasizing the role of gynecologists in early detection.

This study found that a basal 17-hydroxyprogesterone level is effective for screening nonclassic adrenal hyperplasia in women, with a 4 ng/mL cutoff providing high specificity and positive predictive value.

This study found that during late pregnancy in rats, there is an increase in extrasynaptic GABA A receptor number in granule cells of the dentate gyrus, linked to hormonal fluctuations.

This integrative literature review revealed that chronic stress, characterized by elevated cortisol levels, negatively impacts hair follicle integrity and contributes to alopecia by promoting the premature transition from the growth phase to the resting phase of the hair cycle.

This study found that young women with PCOS exhibited altered white matter microstructure and reduced cognitive performance compared to matched controls.

In this study, T3 and T4 were found to directly influence human hair follicles in vitro, enhancing keratinocyte proliferation, prolonging the hair growth phase, and affecting pigmentation.

Treating sleep apnea in young obese women with PCOS can improve heart health and insulin sensitivity.

This study found that inhaled fluticasone for 11 months did not adversely affect the immune function or response to vaccination in horses with heaves.

This review examined studies on erectile dysfunction and 5 alpha-reductase inhibitors, concluding that these drugs do not significantly cause erectile dysfunction and emphasizing testosterone's importance over dihydrotestosterone in erectile function.

This study found that combining Flutamide and an LHRH agonist in adult male rats effectively inhibited prostatic growth and reduced androgen-sensitive prostatic activity markers to levels similar to castrated rats.

This study found that administering a kimchi and cheonggukjang probiotic product promoted hair growth and increased hair thickness in individuals with patterned hair loss without causing adverse effects.

This review discusses the impact of hormones on female sexual function and dysfunction, highlighting the complexity and gaps in basic research, and reports no new clinical findings.

This study explored the structure and function of lipocalin prostaglandin D synthase, revealing its dual role in substrate catalysis and as a lipophilic ligand carrier, potentially informing future drug delivery design.

In this study, 50 mg/day of DHEA supplementation in postmenopausal women did not significantly improve sexual function compared to a placebo over 26 weeks.

In this study, the aqueous extract from Phthirusa pyrifolia leaves significantly decreased testosterone levels in male Wistar rats without causing liver or kidney damage, suggesting potential effects on libido and reproduction.

This review discusses the protective and stress-buffering roles of melatonin in skin functions and structures but does not present new clinical findings.

This study found that hair follicles in both mice and humans may serve as an important site for melatonin synthesis and signaling, potentially influencing hair cycle regulation by modulating keratinocyte apoptosis.

This review examines the sexual side effects of 5α-reductase inhibitors like finasteride, highlighting the increased risk of erectile dysfunction, libido reduction, and potential contribution to depression without new clinical findings.

This study found that while iron depletion through phlebotomies is safe for women with functional ovarian hyperandrogenism, it does not improve their cardio-metabolic profile and may reduce non-enzymatic antioxidant capacity.

This study found that mutant glucocorticoid receptors have defective transcriptional activity and dynamic motility issues in the nucleus, likely due to impaired interactions with nuclear molecules necessary for gene activation.

This study found that the co-activator CBP enhances the agonistic action of hydroxyflutamide on androgen receptors, suggesting a mechanism for therapy resistance in prostate cancer.

Low DHEA-S levels might be linked to alopecia areata and could be a potential treatment target.

This review discusses the role of androgens in menopausal women's health, highlighting symptoms of both hyperandrogenemia and androgen deficiency, but reports no clinical results.

This article reviews assessment and management strategies for adolescent females with excessive hair growth and highlights the importance of evaluating potential androgen sources.

This review discusses the impact of testosterone therapy on postmenopausal women's sexual function and well-being but notes a lack of long-term safety studies and debates on defining androgen insufficiency.