Relationship Between Alopecia, Chronic Stress, and Changes in the Hypothalamic-Pituitary-Adrenal Axis: An Integrative Literature Review
February 2026
in “
Brazilian Journal of Implantology and Health Sciences
”
alopecia chronic stress hypothalamic-pituitary-adrenal axis HPA axis anagen phase telogen phase telogen effluvium cortisol hair follicles hyaluronic acid proteoglycans oxidative stress inflammatory events hair loss stress-induced hair loss growth phase resting phase non-scarring alopecia stress hormone skin components
Studysummary This integrative literature review revealed that chronic stress, characterized by elevated cortisol levels, negatively impacts hair follicle integrity and contributes to alopecia by promoting the premature transition from the growth phase to the resting phase of the hair cycle.
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