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Managing metabolic syndrome needs both lifestyle changes and medical treatments.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Exposure to too much androgen before birth might cause polycystic ovary syndrome later in life.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.

Insulin sensitizers may slightly reduce hirsutism but are less effective than other treatments.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

Eating fewer calories, less sugar and refined carbs, and more low-glycemic and omega-3 rich foods can help manage PCOS symptoms.

Stem cells from hair follicles can safely treat hair loss.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

Targeting the skin's endocannabinoid system could help treat skin disorders.

PCOS in teens is hard to diagnose, linked to genetics and lifestyle, and managed with weight loss and medication.

Women with PCOS have fewer activated T cells in their ovarian follicles, which might affect fertility.

The conclusion is that the best initial treatment for hirsutism is usually oral contraceptives, with the addition of antiandrogens or insulin sensitizers if needed, and topical eflornithine or laser treatments as supplementary options.

Skin problems can be caused or worsened by physical forces and pressure on the skin.

Metformin and rosiglitazone improve blood vessel function in women with PCOS, with metformin also reducing insulin resistance and testosterone levels.

The study found that certain microRNAs are higher in the cells and lower in the fluid of women with a specific type of polycystic ovary syndrome, and one microRNA could potentially help diagnose the condition.

Some skin conditions may indicate metabolic syndrome, which could help with early detection and management of related health issues.

Insulin resistance linked to obesity may increase COVID-19 severity.

The document concludes that more research is needed to understand how to treat muscle pain with drugs.

Dietary changes, including weight loss and a balanced diet, are important for managing PCOS, especially in overweight women.

Understanding the genetics of rare inherited ichthyosis syndromes is key for better treatments and genetic counseling.

Botulinum toxin has potential for treating various skin conditions and improving wound healing.

The document concludes that correct diagnosis and management of PCOS are important, and more research is needed on its risks and treatments.

Understanding how melanocyte stem cells work could lead to new treatments for hair graying and skin pigmentation disorders.

Male hormones, or androgens, affect women's health in areas like mood and bone density, and hormone replacement therapy using antiandrogenic progestogens can improve mood disorders and alertness in menopausal women.

Gene therapy has potential as a future treatment for Hutchinson-Gilford progeria syndrome.

Weight loss and metformin don't significantly change vaspin levels in women with PCOS.