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Researchers created a mouse with the same mutation as humans with trichothiodystrophy, showing similar symptoms and confirming the condition is due to defects in DNA repair and gene activity.

The absence of functional sebaceous glands causes hair follicle destruction and scarring alopecia.

Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.

Skin aging is a complex process influenced by various factors, leading to wrinkles and sagging, and should be considered a disease due to its health impacts.

Both estrogens and androgens are important for health in both males and females.

Wnt signaling is crucial for skin development and hair growth.

Hormones like testosterone and estrogen significantly affect hair growth and structure.

Different treatments for Hidradenitis suppurativa range from antibiotics and hormonal therapies to surgery, depending on severity.

Non-hormonal treatments should be used first for sexual dysfunction in postmenopausal breast cancer patients on aromatase inhibitors, with hormones as a second option.

Progeroid mouse models show signs of early aging similar to humans, helping us understand aging better.

There are two ways to start hair growth: one needs Stat3 and the other does not, but both need PI3K activation.

PCOS management includes lifestyle changes and medications, with ongoing research into repurposed drugs for better treatment options.

Tea, especially green tea, shows promise in cosmetics for skin and hair benefits but more research is needed for effective use.

SCD1 is crucial for skin health and overall energy balance.

Microneedles are effective for painless drug delivery and promoting wound healing and tissue regeneration.

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

New therapies are being developed that target integrin pathways to treat various diseases.

The project created a standardized system for classifying skin lesions in lab rats and mice.

Loss of OGG1 increases skin inflammation and auto-antibodies in lupus.

C/EBPalpha and C/EBPbeta are crucial for normal skin and oil gland cell development in adult mice.

Microneedle technology has advanced for painless drug delivery and sensitive detection but faces a gap between experimental use and clinical needs.

Macrophage iron release is crucial for hair growth and wound healing.

New treatments are needed for PCOS that target its genetic, hormonal, and metabolic causes.

Oral estradiol works for many transgender women but needs personalized dosing and monitoring.

The document concludes that understanding genetic mutations in the PI3K-AKT-mTOR pathway can lead to better diagnosis and treatment for certain genetic skin disorders.

Muscles can make their own androgens, which may help muscle growth.

The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.

Polycystic Ovary Syndrome (PCOS) is not very common among Iranian women, but it's important to prevent it because of the risk of heart disease and infertility.

Androgens play a key role in causing PCOS (Polycystic Ovary Syndrome).

Studying premature aging syndromes helps understand human aging and suggests potential treatments.