38 citations
,
August 2005 in “Veterinary dermatology” This study demonstrates that exfoliative cutaneous lupus erythematosus in German short-haired pointers involves a cellular and humoral immune response against the epidermal basement membrane, with poor response to immunosuppressive therapy.
January 2004 in “Enshou saisei” This study observed that follistatin and activin interactions significantly influence hair follicle development in mice, suggesting potential regenerative treatments for alopecia.
81 citations
,
January 2003 in “The FASEB Journal” This study found that follistatin and activin interactions are important for hair follicle development and cycling in mice, suggesting that they may regulate processes involving BMP-2 and its antagonist.
45 citations
,
October 2008 in “Cytokine & Growth Factor Reviews” This review discusses the role of activin signaling in hair follicle formation, hair growth cycling, and skin healing, but presents no new clinical findings.
Activin A and Follistatin affect how mouse hair follicles grow.
28 citations
,
December 2008 in “Laboratory investigation” This study observed that selectively activating activin in the epidermis of mice enhanced reepithelialization during wound healing without altering the quality of the healed wound.
March 2026 in “Journal of Investigative Dermatology” Folliculin slows hair growth, and blocking it might help treat hair loss.
This study found that activin B promotes the initiation and development of hair follicles in cultured and neonatal mice.
15 citations
,
June 2019 in “eLife” This study identified Activin A and follistatin as key regulators of hair cell differentiation in the mammalian auditory sensory epithelium, with Activin A signaling influencing the timing and pattern of cell differentiation.
5 citations
,
January 2013 in “Cells Tissues Organs” This study found that activin B promotes the initiation and development of hair follicles in both cultured and neonatal mouse skin models.
This study observed that activin A and its antagonist follistatin influence the differentiation of inner ear hair cells by regulating the expression of the transcription factor ATOH1.
5 citations
,
October 2016 in “Experimental Dermatology” This study found that activin A signaling is crucial for hair follicle neogenesis in human dermal papilla 3D cultures combined with mouse epidermal cells.
This study identified Activin A and its antagonist follistatin as crucial regulators of hair cell differentiation in mice, suggesting a local gradient of Activin A influences auditory sensory epithelium development.
7 citations
,
May 2013 in “PubMed” In this randomized, placebo-controlled study, the tested cosmetic ingredient containing Trifolium pratense flower extract and a biomimetic peptide increased anagen hair and improved the anagen/telogen ratio over four months in individuals with recessing hair.
44 citations
,
January 2006 in “Biological & Pharmaceutical Bulletin” This research suggests that testosterone-induced expression of TGF-beta1 and type I procollagen may lead to perifollicular fibrosis in androgenetic alopecia, with finasteride inhibiting this process as a possible mechanism for its effects.
4 citations
,
July 2014 in “Journal of Investigative Dermatology” This study suggests that age-related regenerative decline in hair follicles may be due to an imbalance of signals affecting stem cell activation, with follistatin potentially promoting renewal.
This study identifies Activin A and follistatin as key regulators of hair cell differentiation in the mouse auditory sensory epithelium, influencing the timing and pattern of hair cell development.
March 2026 in “FEBS Open Bio” This study found that 5-aminolevulinic acid combined with ferric ammonium citrate stimulated hair follicle growth and induced hair-like structures in human hair follicle models, suggesting its potential as a treatment for hair loss.
81 citations
,
September 2005 in “The American journal of pathology” This study found that activin affects both stromal cells and keratinocytes in skin morphogenesis and repair, with dose-dependent effects on keratinocytes demonstrated through transgenic mouse models.
November 2019 in “British Journal of Dermatology” FOL-005 peptide may help treat excessive hair growth safely.
July 2019 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Activin A speeds up ear hair cell differentiation, while Follistatin slows it down.
1 citations
,
April 2018 in “Journal of Investigative Dermatology” This study found that FZD2 is crucial for hair follicle formation and postnatal growth in mice and has a novel role in regulating early epidermal development, including stratification and cornification.
January 1997 in “The Showa University Journal of Medical Sciences” This study found that dihydrotestosterone significantly reduced the growth rate of perifollicular sheath cells but had no effect on nonfollicular fibroblasts or dermal papilla cells.
August 2026 in “International Journal of Molecular Sciences” This study found that Atractylodes macrocephala Koidz. extract promotes anagen entry and hair regrowth by enhancing dermal papilla cell activity and supporting hair cycle progression in a mouse model.
January 2020 in “Surgical and Cosmetic Dermatology” This study found that a topical hair ampoule containing human follicle stem cells significantly improved hair growth and scalp coverage in women with androgenetic alopecia after four months of use.
37 citations
,
November 2019 in “Journal of Microbiology and Biotechnology” This study found that loliolide enhanced hair growth-related functions in 3D dermal papilla spheroids by activating AKT/β-catenin signaling pathways, with increased expression of related growth factors and genes.
August 2016 in “Journal of Investigative Dermatology” This study observed that the osteopontin-derived peptide FOL-005 inhibited hair growth in human scalp skin models, contrary to its hair growth promotion in mice, supporting further clinical testing for excessive hair growth treatment.
April 2016 in “Journal of Investigative Dermatology” This pilot study suggests that autophagy is crucial for anagen maintenance in human hair follicles, and targeting this process may help manage hair growth disorders.
2 citations
,
November 2007 in “Journal of Investigative Dermatology” This study found that bulge keratinocytes in mice develop resistance to glucocorticoid treatment more slowly than interfollicular keratinocytes and do not significantly aid in repairing glucocorticoid-induced skin atrophy within five days.
January 2014 in “Journal of Investigative Dermatology” Proteins like aPKC and PDGF-AA, substances like adenosine and ATP, and adipose-derived stem cells all play important roles in hair growth and health, and could potentially be used to treat hair loss and skin conditions.