74 citations
,
July 2010 in “The Journal of Clinical Endocrinology & Metabolism” This study found that gonadal dysfunction is very common in premenopausal women with acromegaly and may be caused by hyperprolactinemia, GH/IGF-I excess, or tumor effects.
66 citations
,
August 1999 in “The Journal of Clinical Endocrinology & Metabolism” This study found that menstrual irregularity is common in women with acromegaly, with high GH levels, estrogen deficiency, and larger tumors correlating with more severe irregularity.
31 citations
,
March 1963 in “American journal of diseases of children” This report details a case of acrodermatitis enteropathica in a 4-month-old infant, noting the disorder's rarity and familial transmission, and includes a literature review with no new clinical results.
28 citations
,
September 1986 in “Pediatric dermatology” In this study, hair anomalies associated with acrodermatitis enteropathica in a young girl improved significantly after two years of zinc therapy.
18 citations
,
June 2016 in “Clinical and Experimental Dermatology” This case study reports that an infant with maple syrup urine disease developed acrodermatitis dysmetabolica due to low isoleucine levels, and increasing the isoleucine dose improved the condition.
17 citations
,
September 2000 in “Journal of dermatology” This case report describes a rare instance where a child with nonketotic hyperglycinemia developed an acrodermatitis enteropathica-like eruption, likely due to combined zinc and branched chain amino acid deficiencies.
16 citations
,
January 2010 in “Journal of Korean medical science/Journal of Korean Medical Science” This case report presents the first genetically confirmed case of acrodermatitis enteropathica in Korea, identifying compound heterozygous mutations in the SLC39A4 gene in an 8-month-old boy.
13 citations
,
June 2006 in “Pituitary” This article reports on a case where a 26-year-old woman with acromegaloidism was found to have X-tetrasomy, suggesting it should be considered in differential diagnoses due to its potential impact on growth-related genes.
11 citations
,
January 2020 in “BMC pediatrics” This case report identified two new SLC39A4 mutations in twin patients with acrodermatitis enteropathica, suggesting that different mutations in this gene may lead to varying clinical manifestations of the disorder.
9 citations
,
September 2012 in “Clinical Endocrinology” This study found that over half of the patients experienced varying degrees of hair loss after acromegaly surgery, with female patients and those with severe postoperative growth hormone deficiency more commonly affected.
7 citations
,
June 2021 in “JAAD Case Reports” This article reviews the cutaneous manifestations of COVID-19, highlighting their potential as early indicators of infection, and reports no new clinical results.
7 citations
,
July 2004 in “Endocrine practice” This case report highlights how persistent hyperphosphatemia, albeit often overlooked, can precede clinical acromegaly symptoms in women, complicating diagnosis due to overlapping features with oral contraceptive use and polycystic ovary syndrome.
6 citations
,
December 2015 in “International journal of immunopathology and pharmacology” A novel mutation in the SLC39A4 gene was identified in an infant with mild, incomplete acrodermatitis enteropathic symptoms, suggesting genetic testing is beneficial even without the full symptom triad.
6 citations
,
October 2015 in “Clinical Case Reports” This study highlights that scalp hair loss is an underreported side effect of somatostatin analogs therapy, potentially linked to decreased GH/IGF-1 levels or a direct drug effect.
6 citations
,
January 2013 in “Case reports in endocrinology” This article reviews acromegaloid facial appearance syndrome and presents a case in a 57-year-old woman, emphasizing the need for more cases to understand its clinical features and inheritance patterns.
6 citations
,
February 2010 in “Journal of The American Academy of Dermatology” This case report details a 31-year-old woman with a subcutaneous nodule on her hand characterized by necrosis and lymphocytic infiltrate.
6 citations
,
June 2008 in “Journal of the European Academy of Dermatology and Venereology” This paper discusses a case of acrodermatitis continua that was resistant to treatment with etanercept, highlighting the therapeutic challenges faced, but reports no new research results.
6 citations
,
January 2000 in “The Journal of Trace Elements in Experimental Medicine” In this study, an 11-year-old girl with acrodermatitis enteropathica showed significant improvement in symptoms after oral zinc therapy.
5 citations
,
September 2019 in “The Open biomarkers journal” This study found that linoleic acid may help protect against acrylamide toxicity in female albino rats.
5 citations
,
April 2013 in “Nasza Dermatologia Online” This study reports no new clinical results on oral zinc therapy for acrodermatitis enteropathica but provides demographic data and symptom prevalence among thirty affected children.
4 citations
,
July 2019 in “Clinical and experimental dermatology” This abstract does not provide specific study results or findings, but it notes that the publisher is not responsible for the supplemental content's accuracy and functionality, directing any queries to the article's corresponding author.
3 citations
,
June 2025 in “Frontiers in Nutrition” This study reviewed literature on pediatric acrodermatitis enteropathica and found that zinc deficiency occurred in 75.9% of cases, with zinc supplementation showing therapeutic efficacy in 91.4% of patients; however, it was often ineffective in those with underlying metabolic disorders.
3 citations
,
January 2007 in “Korean Journal of Pediatrics” This case study reported that zinc supplementation improved skin lesions and diarrhea in a 4-month-old breast-fed infant with transient acrodermatitis enteropathica, even though her serum zinc level was nearly normal.
2 citations
,
May 2021 in “Case reports in dermatological medicine” This report describes a 28-year-old male with type 1 diabetes who presented with acrodermatitis enteropathica symptoms, highlighting potential challenges in blood glucose control linked to zinc deficiency.
2 citations
,
January 2016 in “Journal of clinical & experimental dermatology research” This case report describes a child with acrodermatitis enteropathica showing dramatic improvement with oral zinc therapy, highlighting the importance of early diagnosis and treatment to prevent severe outcomes.
1 citations
,
January 2025 in “Pediatria i Medycyna Rodzinna” This case report of a 16-month-old girl with acrodermatitis enteropathica, who showed atypical symptoms and normal zinc serum levels, highlights how genetic testing and zinc supplementation led to marked improvement in her condition, underscoring the importance of accurate diagnosis in metabolic disorders.
1 citations
,
May 2019 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study presented two brothers with hereditary acrodermatitis enteropathica who had normal zinc serum levels and experienced skin and hair lesions, but no dental disorders.
1 citations
,
January 2018 in “International Journal of Pharmaceutical Sciences and Drug Research” This study describes the development of a minoxidil gel using the copolymer Sepineo P 600, showing improved spreadability, occlusivity, adhesiveness, and stability compared to minoxidil lotion, without causing skin corrosion, making it a potentially more effective treatment form for alopecia areata.
1 citations
,
April 2016 in “Journal of Investigative Dermatology” Zinc deficiency causes reversible hair loss by disrupting hair growth and stem cell function.
January 2026 in “Environmental Science and Pollution Research” In this study, oral administration of wheat sprout extract significantly protected rats against skin damage caused by acrylamide exposure by enhancing antioxidant defenses, reducing oxidative stress, and preserving skin structure, highlighting its potential as a sustainable protective agent against environmental skin toxins.