Severe Scalp Hair Loss in a Female Patient with Acromegaly Treated with Lanreotide Autogel After Unsuccessful Surgery

October 2015 in “ Clinical Case Reports ”

Cristina Álvarez-Escolá, Jersy Cárdenas-Salas, Beatriz Pelegrina, Angel Sanz‐Valtierra, Beatriz Lecumberri

scalp hair loss Lanreotide Autogel somatostatin analogs GH IGF-1 acromegaly nonscarring diffuse hair loss LA growth hormone insulin-like growth factor 1

TLDR A woman with acromegaly experienced severe hair loss from a drug called Lanreotide Autogel, which improved after stopping the treatment.

The document described a 49-year-old female patient with acromegaly who suffered severe nonscarring diffuse scalp hair loss after being treated with Lanreotide Autogel (LA) following an unsuccessful surgery. The hair loss began after the second dose of LA and was severe enough to warrant discontinuation of the treatment due to the patient's psychological distress. The patient's hair condition improved significantly within 5 months after stopping LA. This case highlighted scalp hair loss as a potential side effect of somatostatin analogs therapy, which may be associated with a rapid decrease in GH/IGF-1 levels, though a direct effect of the drug itself could not be ruled out. The document called for more research to assess hair loss as an indicator of treatment efficacy and its effects on patients' quality of life.

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Research cited in this study

2 / 2 results

research Exogenous IGF-1 Promotes Hair Growth by Stimulating Cell Proliferation and Downregulating TGF-β1 in C57BL/6 Mice In Vivo

53 citations, March 2014 in “Growth Hormone & IGF Research”

IGF-1 injections help mice grow more hair by increasing cell growth and blocking a hair growth inhibitor.

research Scalp Hair Loss After Transsphenoidal Adenomectomy in Patients With Acromegaly

9 citations, September 2012 in “Clinical Endocrinology”

More than half of patients who had acromegaly surgery experienced hair loss, with varying degrees of recovery.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community What treatment helped you with oily scalp/hair loss?

in Chat 8 upvotes 5 months ago

The user has been dealing with an oily scalp, seborrheic dermatitis, and hair loss for 18 months, using finasteride without improvement. Another user suggested dutasteride for reducing scalp oiliness.

community Dutasteride is better than Finasteride. Scalp Testosterone increase WON'T accelerate your hair loss...

in Research/Science 39 upvotes 1 year ago

Dutasteride potentially being more effective than Finasteride in treating hair loss due to its ability to suppress DHT levels more significantly. Dutasteride also has fewer sexual side effects compared to Finasteride.

community What do these pictures say about my hair and scalp if anything? Miniaturization, inflammation, etc.?

in Research/Science 74 upvotes 2 years ago

Hair loss and scalp issues, with people discussing possible treatments such as Nizoral shampoo, Minoxidil, neem oil, and finasteride.

community Estrogen is an anabolic for scalp hair, if you mix it with growth stimulants such as oral minoxidil. All we need is an artificial SARM-estrogen that will work only with hair and will be invisible for the rest of the body + some next level AA only for hair – goodbye hair transplant industry

in Transgender 137 upvotes 3 years ago

Hair loss discussion mentions using estrogen mixed with growth stimulants like oral minoxidil for scalp hair growth. Idea proposed for an artificial SARM-estrogen that only affects hair without body side effects.

community could this be a reason for my hair loss

in Chat 13 upvotes 1 year ago

The post discusses potential links between low vitamin D levels and hair loss, and how correcting this might impact the effectiveness of Minoxidil and Finasteride treatments. The responses vary, with some suggesting that vitamin D deficiency would cause overall scalp hair loss, while others believe it would first affect the most sensitive areas.

Related Research

2 / 2 results

research Severe Scalp Hair Loss in a Female Patient with Acromegaly Treated with Lanreotide Autogel After Unsuccessful Surgery

6 citations, October 2015 in “Clinical Case Reports”

A woman with acromegaly experienced severe hair loss from a drug called Lanreotide Autogel, which improved after stopping the treatment.

research Scalp Hair Loss After Transsphenoidal Adenomectomy in Patients With Acromegaly

9 citations, September 2012 in “Clinical Endocrinology”

More than half of patients who had acromegaly surgery experienced hair loss, with varying degrees of recovery.