Acrodermatitis Enteropathica-Like Eruption in an Infant with Nonketotic Hyperglycinemia

    September 2000 in “ Journal of dermatology
    Joseph A. Samady, Robert A. Schwartz, Lisa B. Shih, Z Piela, W. Clark Lambert, Camila K. Jänniger
    TLDR A baby with a rare metabolic disorder developed a rash not cured by zinc alone, likely due to both zinc and amino acid deficiencies.
    The document described a case of a 26-month-old boy with nonketotic hyperglycinemia who developed an acrodermatitis enteropathica-like eruption. This condition, typically caused by zinc deficiency, was complicated by the boy's low protein diet aimed at managing his elevated glycine levels, leading to deficiencies in both zinc and branched chain amino acids. The rash did not improve with zinc supplementation alone, indicating that the eruption was due to a combination of these deficiencies. This case was notable as the first to link acrodermatitis enteropathica-like eruptions with nonketotic hyperglycinemia, expanding the understanding of conditions that can cause similar dermatological symptoms.
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